Targeting a ceramide double bond improves insulin resistance and hepatic steatosis.
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| Title: | Targeting a ceramide double bond improves insulin resistance and hepatic steatosis. |
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| Authors: | Chaurasia, Bhagirath, Tippetts, Trevor S., Monibas, Rafael Mayoral, Liu, Jinqi, Li, Ying, Wang, Liping, Wilkerson, Joseph L., Sweeney, C. Rufus, Pereira, Renato Felipe, Sumida, Doris Hissako, Maschek, J. Alan, Cox, James E., Kaddai, Vincent, Lancaster, Graeme Iain, Siddique, Monowarul Mobin, Poss, Annelise, Pearson, Mackenzie, Satapati, Santhosh, Zhou, Heather, McLaren, David G. |
| Source: | Science (pre-March 2025). 7/26/2019, Vol. 365 Issue 6451, p386-392. 7p. 1 Color Photograph, 3 Diagrams. |
| Subjects: | Ceramides, Glycosphingolipids, Laboratory mice, Genetic engineering, Fatty degeneration, Fatty liver, Metabolic disorders |
| Abstract: | A study which deleted the enzyme dihydroceramide desaturase 1 (DES1) by genetically engineering a mice to determine the impact of the inhibition of DES1 on hepatic steatosis and metabolic disorders, is presented. Topics covered include role of ceramides in the lipotoxicity in diabetes, hepatic steatosis and heart disease, and the impact of dihydroceramides which lacked the critical double bond of ceramides on lipid uptake and storage and glucose utilization. |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | A study which deleted the enzyme dihydroceramide desaturase 1 (DES1) by genetically engineering a mice to determine the impact of the inhibition of DES1 on hepatic steatosis and metabolic disorders, is presented. Topics covered include role of ceramides in the lipotoxicity in diabetes, hepatic steatosis and heart disease, and the impact of dihydroceramides which lacked the critical double bond of ceramides on lipid uptake and storage and glucose utilization. |
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| ISSN: | 00368075 |
| DOI: | 10.1126/science.aav3722 |
