Bibliographic Details
| Title: |
Inactivating and Non-inactivating Potassium Currents in Isolated Inner Hair Cells from Guinea Pig Cochlea. |
| Authors: |
Kimitsuki, Takashi, Ohashi, Mitsuru, Wada, Yuki, Fukudome, Shinji, Komune, Shizuo |
| Source: |
Acta Oto-Laryngologica (Supplement). Aug2004 Supplement 553, Vol. 124, p28-32. 5p. 4 Diagrams, 1 Graph. |
| Subjects: |
Hair cells, Corti's organ, Guinea pigs, Aminopyridines, Pyridine |
| Abstract: |
Using conventional whole-cell voltage-clamp recordings, we examined the 4-aminopyridine (4-AP)- and tetraethylammonium (TEA)-sensitive K + currents in the cochlear inner hair cells (IHCs) of guinea pigs. 4-AP-sensitive currents were activated slowly and sustained the same current level, whereas TEA-sensitive currents were activated rapidly, followed by inactivation. The inactivation time course of TEA-sensitive currents was voltage-dependent, becoming faster at more depolarized levels. The inactivation of TEA-sensitive currents almost recovered within 5 ms. 4-AP- and TEA-sensitive K + currents coexisted in the same IHC. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
