Bibliographic Details
| Title: |
Neurocognitive Effects of Zidovudine and 2', 3'-Dideoxyinosine During the Treatment of Asymptomatic and Symptomatic HIV-1 Seropositive Patients. Comparison with Non-Treated Patients. |
| Authors: |
De Ronchi, D., Lazzari, C., Rucci, P., Cangialosi, A., Volterra, V. |
| Source: |
Human Psychopharmacology: Clinical & Experimental. Sep/Oct96, Vol. 11 Issue 5, p415-420. 6p. |
| Subjects: |
Azidothymidine, Antiviral agents, Pharmacodynamics, Neuropsychological tests, Psychopharmacology, Clinical neuropsychology, Medical research |
| Abstract: |
This paper reports the results of the cross-sectional phase of a long-term follow-up investigation, carried out on a sample representative of the broad population of HIV-1 infected patients, with the objective of evaluating the possible neurocognitive effects of zidovudine and 2′, 3′-dideoxyinosine, compared to a group of people who refused antiretroviral therapy. The sample was composed of 88 people, 42 of whom were treated with ZDV at a daily dose of 500–600 mg, 19 with ddI at a daily dose of 400 mg, and 27 with no therapy. To assess the relevance of different antiretroviral therapies on cognitive performance adjusting for demographic and clinical characteristics, a stepwise logistic regression analysis was performed with neuropsychological performance as the dependent variable and age, education, sex, at-risk behaviour, CD4 count, presence of prominent depressive and anxious symptoms, HIV-1 serostatus and type of antiretroviral treatment as independent variables. The results confirm that people with AIDS and AIDS-related complex treated with ZDV and ddI show a better neuropsychological performance when compared to non-treated patients. By examining the mean performance on each of the previous neuropsychological tests, we found that the most impaired functions in untreated patients were related to short-term memory, long-term memory, vocational competence, and ultimate adjustment. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
