Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals.
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| Title: | Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals. |
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| Authors: | Jia Liu, Yoon Seok Kim, Richardson, Claire E., Tom, Ariane, Ramakrishnan, Charu, Birey, Fikri, Katsumata, Toru, Shucheng Chen, Cheng Wang, Xiao Wang, Joubert, Lydia-Marie, Yuenwen Jiang, Huiliang Wang, Fenno, Lief E., Tok, Jeffrey B.-H., Paşca, Sergiu P., Kang Shen, Zhenan Bao, Deisseroth, Karl |
| Source: | Science (pre-March 2025). 3/20/2020, Vol. 367 Issue 6484, p1372-1376. 5p. 4 Diagrams. |
| Subjects: | Tissues, Polymers, Neurons, Cell membranes, Enzymes |
| Abstract: | The structural and functional complexity of multicellular biological systems, such as the brain, are beyond the reach of human design or assembly capabilities. Cells in living organisms may be recruited to construct synthetic materials or structures if treated as anatomically defined compartments for specific chemistry, harnessing biology for the assembly of complex functional structures. By integrating engineered-enzyme targeting and polymer chemistry, we genetically instructed specific living neurons to guide chemical synthesis of electrically functional (conductive or insulating) polymers at the plasma membrane. Electrophysiological and behavioral analyses confirmed that rationally designed, genetically targeted assembly of functional polymers not only preserved neuronal viability but also achieved remodeling of membrane properties and modulated cell type–specific behaviors in freely moving animals. This approach may enable the creation of diverse, complex, and functional structures and materials within living systems. [ABSTRACT FROM AUTHOR] |
| Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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