Conscious perception and the modulatory role of dopamine: no effect of the dopamine D2 agonist cabergoline on visual masking, the attentional blink, and probabilistic discrimination.
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| Title: | Conscious perception and the modulatory role of dopamine: no effect of the dopamine D2 agonist cabergoline on visual masking, the attentional blink, and probabilistic discrimination. |
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| Authors: | Boonstra, E.A (AUTHOR), van Schouwenburg, M.R (AUTHOR), Seth, A.K (AUTHOR), Bauer, M (AUTHOR), Zantvoord, J.B (AUTHOR), Kemper, E.M (AUTHOR), Lansink, C.S (AUTHOR), Slagter, H.A (AUTHOR) |
| Source: | Psychopharmacology. Sep2020, Vol. 237 Issue 9, p2855-2872. 18p. 2 Black and White Photographs, 2 Diagrams, 1 Chart, 8 Graphs. |
| Subjects: | Dopamine agonists, Attentional blink, Dopamine, Cabergoline, Visual perception, Sensory perception, Visual discrimination, Blinking (Physiology) |
| Abstract: | Rationale: Conscious perception is thought to depend on global amplification of sensory input. In recent years, striatal dopamine has been proposed to be involved in gating information and conscious access, due to its modulatory influence on thalamocortical connectivity. Objectives: Since much of the evidence that implicates striatal dopamine is correlational, we conducted a double-blind crossover pharmacological study in which we administered cabergoline—a dopamine D2 agonist—and placebo to 30 healthy participants. Under both conditions, we subjected participants to several well-established experimental conscious-perception paradigms, such as backward masking and the attentional blink task. Results: We found no evidence in support of an effect of cabergoline on conscious perception: key behavioral and event-related potential (ERP) findings associated with each of these tasks were unaffected by cabergoline. Conclusions: Our results cast doubt on a causal role for dopamine in visual perception. It remains an open possibility that dopamine has causal effects in other tasks, perhaps where perceptual uncertainty is more prominent. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 145949198 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Conscious perception and the modulatory role of dopamine: no effect of the dopamine D2 agonist cabergoline on visual masking, the attentional blink, and probabilistic discrimination. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Boonstra%2C+E%2EA%22">Boonstra, E.A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+Schouwenburg%2C+M%2ER%22">van Schouwenburg, M.R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Seth%2C+A%2EK%22">Seth, A.K</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bauer%2C+M%22">Bauer, M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zantvoord%2C+J%2EB%22">Zantvoord, J.B</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kemper%2C+E%2EM%22">Kemper, E.M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lansink%2C+C%2ES%22">Lansink, C.S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Slagter%2C+H%2EA%22">Slagter, H.A</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Sep2020, Vol. 237 Issue 9, p2855-2872. 18p. 2 Black and White Photographs, 2 Diagrams, 1 Chart, 8 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Dopamine+agonists%22">Dopamine agonists</searchLink><br /><searchLink fieldCode="DE" term="%22Attentional+blink%22">Attentional blink</searchLink><br /><searchLink fieldCode="DE" term="%22Dopamine%22">Dopamine</searchLink><br /><searchLink fieldCode="DE" term="%22Cabergoline%22">Cabergoline</searchLink><br /><searchLink fieldCode="DE" term="%22Visual+perception%22">Visual perception</searchLink><br /><searchLink fieldCode="DE" term="%22Sensory+perception%22">Sensory perception</searchLink><br /><searchLink fieldCode="DE" term="%22Visual+discrimination%22">Visual discrimination</searchLink><br /><searchLink fieldCode="DE" term="%22Blinking+%28Physiology%29%22">Blinking (Physiology)</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Rationale: Conscious perception is thought to depend on global amplification of sensory input. In recent years, striatal dopamine has been proposed to be involved in gating information and conscious access, due to its modulatory influence on thalamocortical connectivity. Objectives: Since much of the evidence that implicates striatal dopamine is correlational, we conducted a double-blind crossover pharmacological study in which we administered cabergoline—a dopamine D2 agonist—and placebo to 30 healthy participants. Under both conditions, we subjected participants to several well-established experimental conscious-perception paradigms, such as backward masking and the attentional blink task. Results: We found no evidence in support of an effect of cabergoline on conscious perception: key behavioral and event-related potential (ERP) findings associated with each of these tasks were unaffected by cabergoline. Conclusions: Our results cast doubt on a causal role for dopamine in visual perception. It remains an open possibility that dopamine has causal effects in other tasks, perhaps where perceptual uncertainty is more prominent. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=145949198 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-020-05579-9 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 18 StartPage: 2855 Subjects: – SubjectFull: Dopamine agonists Type: general – SubjectFull: Attentional blink Type: general – SubjectFull: Dopamine Type: general – SubjectFull: Cabergoline Type: general – SubjectFull: Visual perception Type: general – SubjectFull: Sensory perception Type: general – SubjectFull: Visual discrimination Type: general – SubjectFull: Blinking (Physiology) Type: general Titles: – TitleFull: Conscious perception and the modulatory role of dopamine: no effect of the dopamine D2 agonist cabergoline on visual masking, the attentional blink, and probabilistic discrimination. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Boonstra, E.A – PersonEntity: Name: NameFull: van Schouwenburg, M.R – PersonEntity: Name: NameFull: Seth, A.K – PersonEntity: Name: NameFull: Bauer, M – PersonEntity: Name: NameFull: Zantvoord, J.B – PersonEntity: Name: NameFull: Kemper, E.M – PersonEntity: Name: NameFull: Lansink, C.S – PersonEntity: Name: NameFull: Slagter, H.A IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2020 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 237 – Type: issue Value: 9 Titles: – TitleFull: Psychopharmacology Type: main |
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