The value of p16 and HPV DNA in non-tonsillar, non-base of tongue oropharyngeal cancer.
Saved in:
| Title: | The value of p16 and HPV DNA in non-tonsillar, non-base of tongue oropharyngeal cancer. |
|---|---|
| Authors: | Hammarstedt, Lalle (AUTHOR), Holzhauser, Stefan (AUTHOR), Zupancic, Mark (AUTHOR), Kapoulitsa, Fani (AUTHOR), Ursu, Ramona G. (AUTHOR), Ramqvist, Torbjörn (AUTHOR), Haeggblom, Linnea (AUTHOR), Näsman, Anders (AUTHOR), Dalianis, Tina (AUTHOR), Marklund, Linda (AUTHOR) |
| Source: | Acta Oto-Laryngologica. Jan2021, Vol. 141 Issue 1, p89-94. 6p. |
| Subjects: | Gene expression, Papillomaviruses, Squamous cell carcinoma, Survival analysis (Biometry), Tongue tumors, Oropharyngeal cancer |
| Abstract (English): | Oropharyngeal squamous cell carcinoma (OPSCC) is dominated by tonsillar and tongue base carcinomas (TSCC/BOTSCC), but there are carcinomas at other sites, such as uvula/soft palate/pharyngeal wall here defined as other OPSCC. Human papillomavirus (HPV) positive TSCC/BOTSCC have favorable outcome, and the TNM-classification separates OPSCC into HPV mediated (p16INK4a overexpressing, p16+) and HPV unrelated OPSCC (p16INK4a non-overexpressing, p16-) cancer, but the prognostic role of p16+ in other OPSCC is unclear. This study therefore aimed to further investigate the prognostic role of p16+, presence of HPV DNA, or both combined in other OPSCC. 195 other OPSCC, from patients diagnosed 2000–2018 were tested for p16, and/or presence of HPV DNA and the data correlated to outcome. Neither overall survival, nor disease free survival correlated to presence of p16+ or HPV DNA in other OPSCC. p16+ and HPV DNA presence were correlated (p <.0001), but the sensitivity of p16 as a surrogate marker for presence of HPV DNA was low (49%). The data suggest that p16+ (and p16+/HPV DNA) positive other OPSCC should be analyzed cautiously and possibly separately from the HPV mediated OPSCC staging group. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): | 背景：口咽鳞状细胞癌（OPSCC）主要为扁桃体和舌头基础癌（TSCC / BOTSCC）, 但其它部位也会有癌, 例如悬雍垂/软腭/咽壁, 在此定义为其它OPSCC。人乳头瘤病毒（HPV）阳性TSCC / BOTSCC具有良好的结果, TNM分类将OPSCC分为HPV介导的（p16INK4a过表达, p16 þ）与HPV不相关的OPSCC（p16INK4a非过表达, p16-）癌症, 但是p16þ在其它OPSCC中的预后作用尚不清楚。 目的：本研究旨在进一步研究p16þ、HPV DNA的存在或两者在其他OPSCC中联合使用的预后作用。 材料和方法：对2000年至2018年确诊的195例其它OPSCC进行了p16、和/或HPV DNA存在以及与结果相关的数据的测试。 结果：在其它OPSCC中, 总体生存率和无病生存率均与p16þ或HPV DNA的存在无关。 p16þ和HPV DNA的存在是相关的（p <.0001）, 但是作为HPV DNA存在的替代标志物, p16的敏感性很低（49％）。 结论和意义：数据表明, 其它OPSCC中的p16þ（以及p16þ/ HPV DNA）阳性应得以仔细分析, 并可能与HPV介导的OPSCC分期组分开进行分析。 [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
|
Full text is not displayed to guests.
Login for full access.
|
|
| Abstract: | Oropharyngeal squamous cell carcinoma (OPSCC) is dominated by tonsillar and tongue base carcinomas (TSCC/BOTSCC), but there are carcinomas at other sites, such as uvula/soft palate/pharyngeal wall here defined as other OPSCC. Human papillomavirus (HPV) positive TSCC/BOTSCC have favorable outcome, and the TNM-classification separates OPSCC into HPV mediated (p16INK4a overexpressing, p16+) and HPV unrelated OPSCC (p16INK4a non-overexpressing, p16-) cancer, but the prognostic role of p16+ in other OPSCC is unclear. This study therefore aimed to further investigate the prognostic role of p16+, presence of HPV DNA, or both combined in other OPSCC. 195 other OPSCC, from patients diagnosed 2000–2018 were tested for p16, and/or presence of HPV DNA and the data correlated to outcome. Neither overall survival, nor disease free survival correlated to presence of p16+ or HPV DNA in other OPSCC. p16+ and HPV DNA presence were correlated (p <.0001), but the sensitivity of p16 as a surrogate marker for presence of HPV DNA was low (49%). The data suggest that p16+ (and p16+/HPV DNA) positive other OPSCC should be analyzed cautiously and possibly separately from the HPV mediated OPSCC staging group. [ABSTRACT FROM AUTHOR] |
|---|---|
| ISSN: | 00016489 |
| DOI: | 10.1080/00016489.2020.1813906 |
