Cell type‐specific DNA methylation analysis of the prefrontal cortex of patients with schizophrenia.
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| Title: | Cell type‐specific DNA methylation analysis of the prefrontal cortex of patients with schizophrenia. |
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| Authors: | Ueda, Junko (AUTHOR), Bundo, Miki (AUTHOR), Nakachi, Yutaka (AUTHOR), Kasai, Kiyoto (AUTHOR), Kato, Tadafumi (AUTHOR), Iwamoto, Kazuya (AUTHOR) |
| Source: | Psychiatry & Clinical Neurosciences. Sep2021, Vol. 75 Issue 9, p297-299. 3p. 1 Graph. |
| Subjects: | DNA analysis, Prefrontal cortex, People with schizophrenia, DNA methylation, Gene ontology, Genome-wide association studies |
| Abstract: | Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis. Epigenetics reflects complex interactions between genes and the environment and plays a role in long-lasting gene expression changes. DNA methylation profiles were obtained with promoter tiling arrays covering 25 500 human promoters. We identified 91 DMRs and 69 DMR-associated genes in nonneurons and 74 DMRs and 59 DMR-associated genes in neurons (Tables S2 and S3). [Extracted from the article] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis. Epigenetics reflects complex interactions between genes and the environment and plays a role in long-lasting gene expression changes. DNA methylation profiles were obtained with promoter tiling arrays covering 25 500 human promoters. We identified 91 DMRs and 69 DMR-associated genes in nonneurons and 74 DMRs and 59 DMR-associated genes in neurons (Tables S2 and S3). [Extracted from the article] |
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| ISSN: | 13231316 |
| DOI: | 10.1111/pcn.13282 |
