Arterial stiffness in underweight and weight‐restored anorexia nervosa.

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Bibliographic Details
Title:	Arterial stiffness in underweight and weight‐restored anorexia nervosa.
Authors:	Jenkins, Zoe M. (AUTHOR), Phillipou, Andrea (AUTHOR), Castle, David J. (AUTHOR), Eikelis, Nina (AUTHOR), Lambert, Elisabeth A. (AUTHOR)
Source:	Psychophysiology. Nov2021, Vol. 58 Issue 11, p1-14. 14p. 5 Charts, 2 Graphs.
Subjects:	Arterial diseases, Anorexia nervosa, Pulse wave analysis, Cardiovascular diseases, Cardiological manifestations of general diseases
Abstract:	Cardiovascular complications have been demonstrated in patients with anorexia nervosa (AN) in both the state of starvation and during weight restoration, however, the underlying mechanisms remain unclear. The current study aimed to assess arterial stiffness via carotid‐femoral pulse wave velocity (cfPWV) in the acute and weight‐restored states of AN. The study also aimed to determine the association between psychological distress and cfPWV. The sample included 37 participants; 10 participants with AN, 17 who were weight‐restored (AN‐WR; minimum body mass index >18.5 for at least 12 months) and 10 healthy controls (HCs). cfPWV via applanation tonometry was conducted to assess arterial stiffness. Psychological distress was assessed using the depression anxiety stress scale (DASS‐21) and the state‐trait anxiety inventory (STAI). Between‐group comparisons were performed to determine differences between groups, a two‐stage hierarchical regression model was performed to determine the contribution of physiological and psychological variables on cfPWV and correlation analyses were also performed. Vascular stiffness was significantly increased in the AN and AN‐WR groups, relative to HCs. The total DASS score was the only significant predictor of cfPWV across the sample. There were positive associations between cfPWV and depression, anxiety and stress, as assessed by the DASS. Furthermore, cfPWV was positively associated with STAI trait anxiety. Arterial stiffness was increased in individuals in the acute and weight‐restored states of AN, demonstrating early signs of the development of arteriosclerotic cardiovascular disease. Increased arterial stiffness was associated with increased psychological distress, which may be a contributing mechanism to the increased cardiovascular risk in AN. Cardiovascular complications have been demonstrated in patients with anorexia nervosa, in both the state of starvation and during the process of weight restoration. This study demonstrated increased arterial stiffness in underweight and weight‐restored anorexia nervosa, which was positively associated with depression and anxiety. This finding demonstrates that cardiovascular risk persists despite weight restoration and discusses important implications for the mechanisms underlying the development of cardiovascular disease in anorexia nervosa. [ABSTRACT FROM AUTHOR]
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Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	Cardiovascular complications have been demonstrated in patients with anorexia nervosa (AN) in both the state of starvation and during weight restoration, however, the underlying mechanisms remain unclear. The current study aimed to assess arterial stiffness via carotid‐femoral pulse wave velocity (cfPWV) in the acute and weight‐restored states of AN. The study also aimed to determine the association between psychological distress and cfPWV. The sample included 37 participants; 10 participants with AN, 17 who were weight‐restored (AN‐WR; minimum body mass index >18.5 for at least 12 months) and 10 healthy controls (HCs). cfPWV via applanation tonometry was conducted to assess arterial stiffness. Psychological distress was assessed using the depression anxiety stress scale (DASS‐21) and the state‐trait anxiety inventory (STAI). Between‐group comparisons were performed to determine differences between groups, a two‐stage hierarchical regression model was performed to determine the contribution of physiological and psychological variables on cfPWV and correlation analyses were also performed. Vascular stiffness was significantly increased in the AN and AN‐WR groups, relative to HCs. The total DASS score was the only significant predictor of cfPWV across the sample. There were positive associations between cfPWV and depression, anxiety and stress, as assessed by the DASS. Furthermore, cfPWV was positively associated with STAI trait anxiety. Arterial stiffness was increased in individuals in the acute and weight‐restored states of AN, demonstrating early signs of the development of arteriosclerotic cardiovascular disease. Increased arterial stiffness was associated with increased psychological distress, which may be a contributing mechanism to the increased cardiovascular risk in AN. Cardiovascular complications have been demonstrated in patients with anorexia nervosa, in both the state of starvation and during the process of weight restoration. This study demonstrated increased arterial stiffness in underweight and weight‐restored anorexia nervosa, which was positively associated with depression and anxiety. This finding demonstrates that cardiovascular risk persists despite weight restoration and discusses important implications for the mechanisms underlying the development of cardiovascular disease in anorexia nervosa. [ABSTRACT FROM AUTHOR]
ISSN:	00485772
DOI:	10.1111/psyp.13913