Bibliographic Details
| Title: |
Risk of schizophrenia in patients with polycystic ovary syndrome: a nationwide population-based cohort study from Taiwan. |
| Authors: |
Chen, Shih-Fen (AUTHOR), Yang, Yu-Cih (AUTHOR), Hsu, Chung-Y (AUTHOR), Shen, Yu-Chih (AUTHOR) |
| Source: |
Journal of Psychosomatic Obstetrics & Gynecology. Dec 2021, Vol. 42 Issue 4, p272-278. 7p. |
| Subjects: |
Polyendocrine metabolic ovarian syndrome, 22q11 deletion syndrome, People with schizophrenia, Cohort analysis, Diagnosis, Regression analysis, Research, Schizophrenia, Evaluation research, Comparative studies, Metformin, Longitudinal method, Disease complications |
| Geographic Terms: |
Taiwan |
| Abstract: |
Objectives: To investigate whether patients with polycystic ovary syndrome (PCOS) are at increased risk for incident schizophrenia and whether PCOS treatment (clomiphene, cyproterone, or metformin) affects the incidence of schizophrenia.Methods: An overall of 7146 PCOS patients and 28,580 non-PCOS controls matched by age, index year, and Charlson Comorbidity Index (CCI) score were included between 2000 and 2012 and followed up until 2013 using a validated nationally representative sample from Taiwan. Participants newly diagnosed as schizophrenia were defined as incidents. Cox regression analysis was used to calculate the hazard ratio (HR) with a 95% confidence interval (CI) of the schizophrenia incidence rate between the two studied groups.Results: PCOS patients were at increased risk of incident schizophrenia compared to non-PCOS controls after adjusting for age, CCI score, comorbidities, and different treatment options (0.49 versus 0.09 per 1000 person-years, HR: 6.93, 95% CI: 3.25-14.7). After adjusting for above-mentioned covariates, metformin treatment had a protective effect against the incident schizophrenia compared to non-users (HR: 0.16, 95% CI: 0.06-0.41). Also, treatment with clomiphene and cyproterone had only a limited impact on the incident schizophrenia.Conclusion: This study shows PCOS patients are at increased risk of incident schizophrenia, and the metformin treatment has a protective effect against incident schizophrenia. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
