Face pareidolia is associated with right striatal dysfunction in drug-naïve patients with Parkinson's disease.

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Title:	Face pareidolia is associated with right striatal dysfunction in drug-naïve patients with Parkinson's disease.
Authors:	Murakami, Hidetomo (AUTHOR), Shiraishi, Tomotaka (AUTHOR), Umehara, Tadashi (AUTHOR), Omoto, Shusaku (AUTHOR), Takahashi, Maki (AUTHOR), Motegi, Haruhiko (AUTHOR), Maku, Takahiro (AUTHOR), Sato, Takeo (AUTHOR), Takatsu, Hiroki (AUTHOR), Komatsu, Teppei (AUTHOR), Bono, Keiko (AUTHOR), Sakai, Kenichiro (AUTHOR), Mitsumura, Hidetaka (AUTHOR), Iguchi, Yasuyuki (AUTHOR)
Source:	Neurological Sciences. Dec2021, Vol. 42 Issue 12, p5327-5334. 8p. 1 Black and White Photograph, 2 Charts, 1 Graph.
Subjects:	Parkinson's disease, Caudate nucleus, Optical information processing
Abstract:	Background and aim: Some patients with Parkinson's disease (PD) present with pareidolia, an illusion of a meaningless stimulus as a familiar object known to the observer. Since the striatum is associated with processing of visual information, we investigated correlations of pareidolia with motor symptoms and striatal dopaminergic function. Method: A noise pareidolia test, assessment of motor symptoms using MDS-UPDRS and 123I-Ioflupane SPECT were performed in 58 drug-naïve PD patients. A number of images in which a participant noticed an illusory face (number of illusory responses) were compared with motor assessment scores and uptake of 123I-ioflupane in the striatum. Results: Of the 58 participants, 22 had at least one illusory response. Mean scores for MDS-UPDRS part III (p<0.05), rigidity (p<0.05), and rigidity on the left side of the body (p<0.01) in patients with pareidolia were significantly higher than those in patients without pareidolia. Uptake of 123I-ioflupane in the right caudate nucleus (p<0.05), anterior putamen (p<0.01), and posterior putamen (p<0.01) in patients with pareidolia was significantly lower than in patients without pareidolia. In the 22 patients with pareidolia, the number of illusory responses was significantly correlated with total scores for MDS-UPDRS part III (r=0.443, p<0.05) and subscores for bradykinesia (r=0.440, p<0.05) and bradykinesia on the left side of the body (r=0.564, p<0.01). The prevalence of pareidolia in left-dominant parkinsonism (16/30 patients) was higher than that in right-dominant parkinsonism (6/28 patients) (p<0.05 by chi-square test). Conclusion: Pareidolia in PD patients is associated with dysfunction in the right striatum. [ABSTRACT FROM AUTHOR]
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Database:	Psychology and Behavioral Sciences Collection

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Abstract:	Background and aim: Some patients with Parkinson's disease (PD) present with pareidolia, an illusion of a meaningless stimulus as a familiar object known to the observer. Since the striatum is associated with processing of visual information, we investigated correlations of pareidolia with motor symptoms and striatal dopaminergic function. Method: A noise pareidolia test, assessment of motor symptoms using MDS-UPDRS and 123I-Ioflupane SPECT were performed in 58 drug-naïve PD patients. A number of images in which a participant noticed an illusory face (number of illusory responses) were compared with motor assessment scores and uptake of 123I-ioflupane in the striatum. Results: Of the 58 participants, 22 had at least one illusory response. Mean scores for MDS-UPDRS part III (p<0.05), rigidity (p<0.05), and rigidity on the left side of the body (p<0.01) in patients with pareidolia were significantly higher than those in patients without pareidolia. Uptake of 123I-ioflupane in the right caudate nucleus (p<0.05), anterior putamen (p<0.01), and posterior putamen (p<0.01) in patients with pareidolia was significantly lower than in patients without pareidolia. In the 22 patients with pareidolia, the number of illusory responses was significantly correlated with total scores for MDS-UPDRS part III (r=0.443, p<0.05) and subscores for bradykinesia (r=0.440, p<0.05) and bradykinesia on the left side of the body (r=0.564, p<0.01). The prevalence of pareidolia in left-dominant parkinsonism (16/30 patients) was higher than that in right-dominant parkinsonism (6/28 patients) (p<0.05 by chi-square test). Conclusion: Pareidolia in PD patients is associated with dysfunction in the right striatum. [ABSTRACT FROM AUTHOR]
ISSN:	15901874
DOI:	10.1007/s10072-021-05238-7