Fiber selectivity of peripheral neuropathy in patients with Parkinson's disease.
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| Title: | Fiber selectivity of peripheral neuropathy in patients with Parkinson's disease. |
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| Authors: | Xiong, Yi‐Tong (AUTHOR), Liu, Man‐Hua (AUTHOR), Gu, Han‐Ying (AUTHOR), Li, Kai (AUTHOR), Zhang, Jin‐Ru (AUTHOR), Cheng, Xiao‐Yu (AUTHOR), Jin, Hong (AUTHOR), Chen, Jing (AUTHOR), Mao, Cheng‐Jie (AUTHOR), Liu, Chun‐Feng (AUTHOR) |
| Source: | Acta Neurologica Scandinavica. Jul2022, Vol. 146 Issue 1, p75-81. 7p. |
| Subjects: | Parkinson's disease, Peripheral neuropathy, Threshold (Perception), Logistic regression analysis, Vitamin B12 |
| Abstract: | Objective: To determine the function of each type of peripheral nerve fiber and investigate the possible role of levodopa (LD) in peripheral neuropathy (PN) in Parkinson's disease (PD) patients. Methods: We enrolled 60 patients with idiopathic PD. All PD patients were divided into three groups: levodopa exposure >3 years (LELD), levodopa exposure ≤3 years (SELD) and de novo patients with PD (NOLD). The current perception threshold (CPT), which was measured by Neurometer at 2000, 250 and 5 Hz, the level of homocysteine, Vitamin B12 and folic acid in plasma, were compared with those of sex‐ and age‐matched healthy controls (HCs). Results: Current perception threshold was higher at 250 Hz (p <.05) and 5 Hz (p <.05) in the LELD group than the NOLD, SELD, and control group. CPT was lower at 5 Hz in the NOLD than in the HCs group (p <.05). The CPT of the more affected side of PD patients was positively correlated with H‐Y stage at 5 Hz current stimulation (r =.42, p =.01). Multivariate logistic regression analysis showed that elevated homocysteine levels were the risk factor of sensory nerve injury in PD patients (p <.01). Serum homocysteine levels were positively correlated with levodopa (LD) daily dose, LD equivalent daily dose, and LD cumulative lifetime dose (p <.05). Conclusions: Peripheral neuropathy in PD patients can occur in the early stage of PD exhibiting as hyperesthesia and is fiber selectivity, especially for Aδ and C nerve fibers. PN in PD patients is related to PD itself and long‐term LD exposure. Elevated plasma homocysteine is a risk factor for PN in PD patients. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Objective: To determine the function of each type of peripheral nerve fiber and investigate the possible role of levodopa (LD) in peripheral neuropathy (PN) in Parkinson's disease (PD) patients. Methods: We enrolled 60 patients with idiopathic PD. All PD patients were divided into three groups: levodopa exposure >3 years (LELD), levodopa exposure ≤3 years (SELD) and de novo patients with PD (NOLD). The current perception threshold (CPT), which was measured by Neurometer at 2000, 250 and 5 Hz, the level of homocysteine, Vitamin B12 and folic acid in plasma, were compared with those of sex‐ and age‐matched healthy controls (HCs). Results: Current perception threshold was higher at 250 Hz (p <.05) and 5 Hz (p <.05) in the LELD group than the NOLD, SELD, and control group. CPT was lower at 5 Hz in the NOLD than in the HCs group (p <.05). The CPT of the more affected side of PD patients was positively correlated with H‐Y stage at 5 Hz current stimulation (r =.42, p =.01). Multivariate logistic regression analysis showed that elevated homocysteine levels were the risk factor of sensory nerve injury in PD patients (p <.01). Serum homocysteine levels were positively correlated with levodopa (LD) daily dose, LD equivalent daily dose, and LD cumulative lifetime dose (p <.05). Conclusions: Peripheral neuropathy in PD patients can occur in the early stage of PD exhibiting as hyperesthesia and is fiber selectivity, especially for Aδ and C nerve fibers. PN in PD patients is related to PD itself and long‐term LD exposure. Elevated plasma homocysteine is a risk factor for PN in PD patients. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00016314 |
| DOI: | 10.1111/ane.13624 |
