Bibliographic Details
| Title: |
TLR5 and TLR7 are differentially expressed in human papillomavirus-positive and negative base of tongue squamous cell carcinoma, and TLR7 may have an independent prognostic influence. |
| Authors: |
Haeggblom, Linnea, Näsman, Anders, Ramqvist, Torbjorn, Haglund, Caj, Hagstrom, Jaana, Mäkitie, Antti, Dalianis, Tina |
| Source: |
Acta Oto-Laryngologica (Supplement). Feb2019, Vol. 139 Issue 2, p206-210,. 5p. 1 Chart, 1 Graph. |
| Subjects: |
Papillomaviruses, Tongue tumors, Immunohistochemistry, Cell receptors, Gene expression, Descriptive statistics, Tumor markers, Data analysis software, Squamous cell carcinoma, Toll-like receptors |
| Abstract: |
Background: Human papillomavirus-positive (HPV=) base of tongue squamous cell carcinoma (BOTSCC) has a better outcome than corresponding HPV cancer. TLR5 and TLR7 expression was previously shown to differ depending on HPV status and correlate with outcome in oropharyngeal squamous cell carcinoma. Aims/objectives: For validation, TLR5 and TLR7 were analyzed in a BOTSCC-cohort for correlation with HPV, survival, CD4þ and CD8þ tumor-infiltrating lymphocyte (TIL) counts, the latter being a well documented prognostic marker. Materials and methods: BOTSCC biopsies, (49HPV=/28HPV) were analyzed by immunohistochemistry for TLR5 and TLR7, and correlated with the above parameters. Results: TLR5 expression was more frequently absent/weak than medium/strong in HPV= compared to HPV BOTSCC (p < .001). The opposite was observed for TLR7 (p < .007). TLR5 and TLR7 expression did not correlate to survival in either the HPV or HPV= cases, or to CD4þ TILs. TLR5, (but not TLR7) expression was correlated to CD8+ TIL counts (p ¼ .023). Conclusion and significance: Absent/weak TLR5 and medium/strong TLR7 expression was validated as more frequent in HPV= compared with HPV BOTSCC. A correlation between CD8+ TIL counts, and TLR5 expression was disclosed, but not with TLR7. Therefore, it could be useful to investigate TLR7 further as a potential independent prognostic marker. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
