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A cross-sectional study on the association between Helicobacter pylori infection and headache.

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Title: A cross-sectional study on the association between Helicobacter pylori infection and headache.
Authors: Cavestro, Cinzia (AUTHOR), Prandi, Giancarlo (AUTHOR), Manildo, Matteo (AUTHOR), Martini, Sabina (AUTHOR), Genovesi, Corrado (AUTHOR), Premoli, Alberto (AUTHOR), Fraire, Flavio (AUTHOR), Neri, Loris (AUTHOR), Mandrino, Silvia (AUTHOR), Ferrero, Marcella (AUTHOR), Rota, Eugenia (AUTHOR)
Source: Neurological Sciences. Oct2022, Vol. 43 Issue 10, p6031-6038. 8p. 4 Charts, 2 Graphs.
Subjects: Helicobacter disease diagnosis, Migraine complications, Helicobacter pylori, Migraine, Cross-sectional method, Headache, Helicobacter diseases, Disease complications
Abstract: Background: The relationship between chronic Helicobacter pylori (HP) infection and headache has been discussed for long; nevertheless, the results of the studies are still contrasting.Objective: This cross-sectional study is aimed to investigate a possible association between HP and headache, mainly migraine.Methods: We screened, by a self-administered questionnaire, the subjects undergoing a breath test or an esophagogastroduodenoscopy. Migraine was diagnosed according to the international criteria.Results: A total of 3914 patients underwent a breath test and 2200 an esophagogastroduodenoscopy at two hospitals, in Piedmont (Italy), in a 5-year period; a total of 1362 questionnaires were included in the study. The mean age of the subjects was 53 years; there were 777 women (57%). HP was detected in 364 (27%) subjects. A total of 702 (51%) subjects suffered from headache: migraine with aura was diagnosed in 176 subjects (176/702, i.e., 25% of the headache group; 176/1362, i.e., 13% of the total population); migraine without aura in 98 subjects (98/702, i.e., 14% of the headache group; 98/1362, i.e., 7% of the total). The logistic regression model did not detect any significant association between HP infection and headache, while a significant association between HP and headache frequency (p =0.009) was found, independently of age, gender, comorbidity, and diagnostic category.Conclusion: Our study does not reveal an association between chronic HP infection and migraine. However, since HP is significantly associated with higher headache frequency, a role for HP as a risk factor for headache chronification, possibly underlain by inflammatory mechanisms, may be supposed. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: A cross-sectional study on the association between Helicobacter pylori infection and headache.
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  Data: <searchLink fieldCode="AR" term="%22Cavestro%2C+Cinzia%22">Cavestro, Cinzia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Prandi%2C+Giancarlo%22">Prandi, Giancarlo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Manildo%2C+Matteo%22">Manildo, Matteo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Martini%2C+Sabina%22">Martini, Sabina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Genovesi%2C+Corrado%22">Genovesi, Corrado</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Premoli%2C+Alberto%22">Premoli, Alberto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fraire%2C+Flavio%22">Fraire, Flavio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Neri%2C+Loris%22">Neri, Loris</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mandrino%2C+Silvia%22">Mandrino, Silvia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ferrero%2C+Marcella%22">Ferrero, Marcella</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rota%2C+Eugenia%22">Rota, Eugenia</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Oct2022, Vol. 43 Issue 10, p6031-6038. 8p. 4 Charts, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Helicobacter+disease+diagnosis%22">Helicobacter disease diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Migraine+complications%22">Migraine complications</searchLink><br /><searchLink fieldCode="DE" term="%22Helicobacter+pylori%22">Helicobacter pylori</searchLink><br /><searchLink fieldCode="DE" term="%22Migraine%22">Migraine</searchLink><br /><searchLink fieldCode="DE" term="%22Cross-sectional+method%22">Cross-sectional method</searchLink><br /><searchLink fieldCode="DE" term="%22Headache%22">Headache</searchLink><br /><searchLink fieldCode="DE" term="%22Helicobacter+diseases%22">Helicobacter diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+complications%22">Disease complications</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: <bold>Background: </bold>The relationship between chronic Helicobacter pylori (HP) infection and headache has been discussed for long; nevertheless, the results of the studies are still contrasting.<bold>Objective: </bold>This cross-sectional study is aimed to investigate a possible association between HP and headache, mainly migraine.<bold>Methods: </bold>We screened, by a self-administered questionnaire, the subjects undergoing a breath test or an esophagogastroduodenoscopy. Migraine was diagnosed according to the international criteria.<bold>Results: </bold>A total of 3914 patients underwent a breath test and 2200 an esophagogastroduodenoscopy at two hospitals, in Piedmont (Italy), in a 5-year period; a total of 1362 questionnaires were included in the study. The mean age of the subjects was 53 years; there were 777 women (57%). HP was detected in 364 (27%) subjects. A total of 702 (51%) subjects suffered from headache: migraine with aura was diagnosed in 176 subjects (176/702, i.e., 25% of the headache group; 176/1362, i.e., 13% of the total population); migraine without aura in 98 subjects (98/702, i.e., 14% of the headache group; 98/1362, i.e., 7% of the total). The logistic regression model did not detect any significant association between HP infection and headache, while a significant association between HP and headache frequency (p =0.009) was found, independently of age, gender, comorbidity, and diagnostic category.<bold>Conclusion: </bold>Our study does not reveal an association between chronic HP infection and migraine. However, since HP is significantly associated with higher headache frequency, a role for HP as a risk factor for headache chronification, possibly underlain by inflammatory mechanisms, may be supposed. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10072-022-06153-1
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      – Code: eng
        Text: English
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        PageCount: 8
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      – SubjectFull: Helicobacter disease diagnosis
        Type: general
      – SubjectFull: Migraine complications
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      – SubjectFull: Helicobacter pylori
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