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NIN-like protein 7 transcription factor is a plant nitrate sensor.

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Title: NIN-like protein 7 transcription factor is a plant nitrate sensor.
Authors: Liu, Kun-Hsiang, Liu, Menghong, Lin, Ziwei, Wang, Zi-Fu, Chen, Binqing, Liu, Cong, Guo, Aping, Konishi, Mineko, Yanagisawa, Shuichi, Wagner, Gerhard, Sheen, Jen
Source: Science (pre-March 2025). 9/23/2022, Vol. 377 Issue 6613, p1419-1425. 7p. 1 Diagram, 4 Graphs.
Subjects: Nitrates, Plant growth, Arabidopsis proteins, Transcription factors, Plant mutation, N-terminal residues, Chimeras (Botany)
Abstract: Nitrate is an essential nutrient and signaling molecule for plant growth. Plants sense intracellular nitrate to adjust their metabolic and growth responses. Here we identify the primary nitrate sensor in plants. We found that mutation of all seven Arabidopsis NIN-like protein (NLP) transcription factors abolished plantsÕ primary nitrate responses and developmental programs. Analyses of NIN-NLP7 chimeras and nitrate binding revealed that NLP7 is derepressed upon nitrate perception via its amino terminus. A genetically encoded fluorescent split biosensor, mCitrine-NLP7, enabled visualization of single-cell nitrate dynamics in planta. The nitrate sensor domain of NLP7 resembles the bacterial nitrate sensor NreA. Substitutions of conserved residues in the ligand-binding pocket impaired the ability of nitrate-triggered NLP7 to control transcription, transport, metabolism, development, and biomass. We propose that NLP7 represents a nitrate sensor in land plants. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: NIN-like protein 7 transcription factor is a plant nitrate sensor.
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  Data: <searchLink fieldCode="AR" term="%22Liu%2C+Kun-Hsiang%22">Liu, Kun-Hsiang</searchLink><br /><searchLink fieldCode="AR" term="%22Liu%2C+Menghong%22">Liu, Menghong</searchLink><br /><searchLink fieldCode="AR" term="%22Lin%2C+Ziwei%22">Lin, Ziwei</searchLink><br /><searchLink fieldCode="AR" term="%22Wang%2C+Zi-Fu%22">Wang, Zi-Fu</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Binqing%22">Chen, Binqing</searchLink><br /><searchLink fieldCode="AR" term="%22Liu%2C+Cong%22">Liu, Cong</searchLink><br /><searchLink fieldCode="AR" term="%22Guo%2C+Aping%22">Guo, Aping</searchLink><br /><searchLink fieldCode="AR" term="%22Konishi%2C+Mineko%22">Konishi, Mineko</searchLink><br /><searchLink fieldCode="AR" term="%22Yanagisawa%2C+Shuichi%22">Yanagisawa, Shuichi</searchLink><br /><searchLink fieldCode="AR" term="%22Wagner%2C+Gerhard%22">Wagner, Gerhard</searchLink><br /><searchLink fieldCode="AR" term="%22Sheen%2C+Jen%22">Sheen, Jen</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 9/23/2022, Vol. 377 Issue 6613, p1419-1425. 7p. 1 Diagram, 4 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Nitrates%22">Nitrates</searchLink><br /><searchLink fieldCode="DE" term="%22Plant+growth%22">Plant growth</searchLink><br /><searchLink fieldCode="DE" term="%22Arabidopsis+proteins%22">Arabidopsis proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Transcription+factors%22">Transcription factors</searchLink><br /><searchLink fieldCode="DE" term="%22Plant+mutation%22">Plant mutation</searchLink><br /><searchLink fieldCode="DE" term="%22N-terminal+residues%22">N-terminal residues</searchLink><br /><searchLink fieldCode="DE" term="%22Chimeras+%28Botany%29%22">Chimeras (Botany)</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Nitrate is an essential nutrient and signaling molecule for plant growth. Plants sense intracellular nitrate to adjust their metabolic and growth responses. Here we identify the primary nitrate sensor in plants. We found that mutation of all seven Arabidopsis NIN-like protein (NLP) transcription factors abolished plantsÕ primary nitrate responses and developmental programs. Analyses of NIN-NLP7 chimeras and nitrate binding revealed that NLP7 is derepressed upon nitrate perception via its amino terminus. A genetically encoded fluorescent split biosensor, mCitrine-NLP7, enabled visualization of single-cell nitrate dynamics in planta. The nitrate sensor domain of NLP7 resembles the bacterial nitrate sensor NreA. Substitutions of conserved residues in the ligand-binding pocket impaired the ability of nitrate-triggered NLP7 to control transcription, transport, metabolism, development, and biomass. We propose that NLP7 represents a nitrate sensor in land plants. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1126/science.add1104
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        Text: English
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        PageCount: 7
        StartPage: 1419
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      – SubjectFull: Nitrates
        Type: general
      – SubjectFull: Plant growth
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      – SubjectFull: Arabidopsis proteins
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      – SubjectFull: Transcription factors
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      – SubjectFull: Plant mutation
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      – SubjectFull: N-terminal residues
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      – SubjectFull: Chimeras (Botany)
        Type: general
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      – TitleFull: NIN-like protein 7 transcription factor is a plant nitrate sensor.
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            – D: 23
              M: 09
              Text: 9/23/2022
              Type: published
              Y: 2022
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