Cortical thickness across the cingulate gyrus in schizophrenia and its association to illness duration and memory performance.
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| Title: | Cortical thickness across the cingulate gyrus in schizophrenia and its association to illness duration and memory performance. |
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| Authors: | Thielen, J.-W. (AUTHOR), Müller, B. W. (AUTHOR), Chang, D.-I. (AUTHOR), Krug, A. (AUTHOR), Mehl, S. (AUTHOR), Rapp, A. (AUTHOR), Walter, H. (AUTHOR), Winterer, G. (AUTHOR), Vogeley, K. (AUTHOR), Klingberg, S. (AUTHOR), Wagner, M. (AUTHOR), Kircher, T. (AUTHOR) |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. Oct2022, Vol. 272 Issue 7, p1241-1251. 11p. 1 Color Photograph, 1 Diagram, 3 Charts, 1 Graph. |
| Subjects: | Cingulate cortex, Schizophrenia, Episodic memory, Brain abnormalities, Neuroplasticity, Visual fields |
| Abstract: | Schizophrenia has been associated with structural brain abnormalities and cognitive deficits that partly change during the course of illness. In the present study, cortical thickness in five subregions of the cingulate gyrus was assessed in 44 patients with schizophrenia-spectrum disorder and 47 control persons and related to illness duration and memory capacities. In the patients group, cortical thickness was increased in the posterior part of the cingulate gyrus and related to illness duration whereas cortical thickness was decreased in anterior parts unrelated to illness duration. In contrast, cortical thickness was related to episodic and working memory performance only in the anterior but not posterior parts of the cingulate gyrus. Our finding of a posterior cingulate increase may point to either increased parietal communication that is accompanied by augmented neural plasticity or to effects of altered neurodegenerative processes in schizophrenia. [ABSTRACT FROM AUTHOR] |
| Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Schizophrenia has been associated with structural brain abnormalities and cognitive deficits that partly change during the course of illness. In the present study, cortical thickness in five subregions of the cingulate gyrus was assessed in 44 patients with schizophrenia-spectrum disorder and 47 control persons and related to illness duration and memory capacities. In the patients group, cortical thickness was increased in the posterior part of the cingulate gyrus and related to illness duration whereas cortical thickness was decreased in anterior parts unrelated to illness duration. In contrast, cortical thickness was related to episodic and working memory performance only in the anterior but not posterior parts of the cingulate gyrus. Our finding of a posterior cingulate increase may point to either increased parietal communication that is accompanied by augmented neural plasticity or to effects of altered neurodegenerative processes in schizophrenia. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 09401334 |
| DOI: | 10.1007/s00406-021-01369-2 |
