Impaired delay discounting and time sensitivity in methcathinone use disorder.
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| Title: | Impaired delay discounting and time sensitivity in methcathinone use disorder. |
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| Authors: | Zeng, Ningning (AUTHOR), Zheng, Hui (AUTHOR), Shi, Tianshu (AUTHOR), Zhang, Hang-Bin (AUTHOR), Wang, Li-Xun (AUTHOR), Liang, Zhu-Yuan (AUTHOR), Sun, Bomin (AUTHOR), Liao, Yanhui (AUTHOR), Rao, Li-Lin (AUTHOR), Yang, Bo (AUTHOR), Yuan, Ti-Fei (AUTHOR) |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. Dec2022, Vol. 272 Issue 8, p1595-1602. 8p. 1 Chart, 4 Graphs. |
| Subjects: | Delay discounting (Psychology), Time perception, Task performance, Substance abuse, Drug utilization, Decision making |
| Abstract: | Substance use disorder (SUD) is characterized by continued drug use despite adverse consequences. Methcathinone is a new type of psychoactive substance that is associated with high excitement and impulsive behaviors. However, it is unclear if individuals with methcathinone use disorders (MCUD) are with impaired decision-making ability. We analyzed the task performance in 45 male MCUD subjects and 35 male matched healthy controls (HC) with intertemporal decision-making task. Constant sensitivity discounting model was used to estimate potential changes in both discounting rate and time sensitivity. The results showed that MCUD individuals exhibited a higher delay discounting rate (p = 0.003, Cohen's d = 0.683) and reduced sensitivity to time (p < 0.001, Cohen's d = 1.662). The delay discounting rate was correlated to the first age for drug use (r = − 0.41, p = 0.004), and the time sensitivity was negatively correlated with the duration of abstinence (r = − 0.31, p = 0.036). We conclude that MCUD individuals are with impaired decision-making ability and time perception disturbances. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Substance use disorder (SUD) is characterized by continued drug use despite adverse consequences. Methcathinone is a new type of psychoactive substance that is associated with high excitement and impulsive behaviors. However, it is unclear if individuals with methcathinone use disorders (MCUD) are with impaired decision-making ability. We analyzed the task performance in 45 male MCUD subjects and 35 male matched healthy controls (HC) with intertemporal decision-making task. Constant sensitivity discounting model was used to estimate potential changes in both discounting rate and time sensitivity. The results showed that MCUD individuals exhibited a higher delay discounting rate (p = 0.003, Cohen's d = 0.683) and reduced sensitivity to time (p < 0.001, Cohen's d = 1.662). The delay discounting rate was correlated to the first age for drug use (r = − 0.41, p = 0.004), and the time sensitivity was negatively correlated with the duration of abstinence (r = − 0.31, p = 0.036). We conclude that MCUD individuals are with impaired decision-making ability and time perception disturbances. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 09401334 |
| DOI: | 10.1007/s00406-021-01372-7 |
