View in EDS HTML Full Text PDF Full Text

Temperament traits mediate the relationship between CACNA1C polymorphisms and bipolar disorder in cisgender women.

Saved in:
Bibliographic Details
Title: Temperament traits mediate the relationship between CACNA1C polymorphisms and bipolar disorder in cisgender women.
Authors: Bastos, Clarissa Ribeiro (AUTHOR), Bock, Bertha Bueno (AUTHOR), Xavier, Janaina (AUTHOR), Camerini, Laísa (AUTHOR), Dewes, Samantha Seibt (AUTHOR), Grellert, Mateus (AUTHOR), de Carvalho, Hudson Wander (AUTHOR), Jansen, Karen (AUTHOR), da Silva, Ricardo Azevedo (AUTHOR), Pinheiro, Ricardo Tavares (AUTHOR), de Mattos Souza, Luciano (AUTHOR), Oses, Jean Pierre (AUTHOR), Portela, Luis Valmor (AUTHOR), Lara, Diogo Rizzato (AUTHOR), Tovo-Rodrigues, Luciana (AUTHOR), Ghisleni, Gabriele (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Feb2023, Vol. 273 Issue 1, p41-50. 10p. 2 Charts, 2 Graphs.
Subjects: Bipolar disorder, Temperament, Sex (Biology), Haplotypes, Cisgender people
Geographic Terms: Pelotas (Rio Grande do Sul, Brazil), Brazil
Abstract: The influence of temperament traits on bipolar disorder (BD) has been investigated. Both temperament traits and BD are partially genetically determined and seem to be influenced by variations in the CACNA1C gene. These variations presented a significant interactive effect with biological sex, although studies that evaluate this relationship are scarce. Here, we assessed the mediation effect of temperament traits on the relationship between two polymorphisms in the CACNA1C gene (rs1006737 and rs4765913) and BD according to sex. This is a cross-sectional study consisting of 878 Caucasian individuals (508 women and 370 men), aged 18–35, enrolled in a population-based study in the city of Pelotas, Southern Brazil. BD diagnosis was evaluated using the clinical interview MINI 5.0, and temperament traits were assessed via the application of the Affective and Emotional Composite Temperament Scale (AFECTS). Mediation models were tested using the modeling tool PROCESS (version 3.3) for SPSS. Bootstrapping-enhanced mediation analyses in women indicated that traits anger (39%) and caution (27%) mediated the association between the rs4765913 SNP and BD, while traits volition (29%), anger (35%), and caution (29%) mediated the association between the AA haplotype (rs1006737–rs4765913) and the BD. No effect was encountered for cisgender men. Our model revealed that paths from CACNA1C SNPs to BD are mediated by specific temperament traits in women, reinforcing the definition of temperament traits as endophenotypes. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 162077176
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Temperament traits mediate the relationship between CACNA1C polymorphisms and bipolar disorder in cisgender women.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Bastos%2C+Clarissa+Ribeiro%22">Bastos, Clarissa Ribeiro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bock%2C+Bertha+Bueno%22">Bock, Bertha Bueno</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xavier%2C+Janaina%22">Xavier, Janaina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Camerini%2C+Laísa%22">Camerini, Laísa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dewes%2C+Samantha+Seibt%22">Dewes, Samantha Seibt</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Grellert%2C+Mateus%22">Grellert, Mateus</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Carvalho%2C+Hudson+Wander%22">de Carvalho, Hudson Wander</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jansen%2C+Karen%22">Jansen, Karen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22da+Silva%2C+Ricardo+Azevedo%22">da Silva, Ricardo Azevedo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pinheiro%2C+Ricardo+Tavares%22">Pinheiro, Ricardo Tavares</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Mattos+Souza%2C+Luciano%22">de Mattos Souza, Luciano</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Oses%2C+Jean+Pierre%22">Oses, Jean Pierre</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Portela%2C+Luis+Valmor%22">Portela, Luis Valmor</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lara%2C+Diogo+Rizzato%22">Lara, Diogo Rizzato</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tovo-Rodrigues%2C+Luciana%22">Tovo-Rodrigues, Luciana</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ghisleni%2C+Gabriele%22">Ghisleni, Gabriele</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Feb2023, Vol. 273 Issue 1, p41-50. 10p. 2 Charts, 2 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Temperament%22">Temperament</searchLink><br /><searchLink fieldCode="DE" term="%22Sex+%28Biology%29%22">Sex (Biology)</searchLink><br /><searchLink fieldCode="DE" term="%22Haplotypes%22">Haplotypes</searchLink><br /><searchLink fieldCode="DE" term="%22Cisgender+people%22">Cisgender people</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Pelotas+%28Rio+Grande+do+Sul%2C+Brazil%29%22">Pelotas (Rio Grande do Sul, Brazil)</searchLink><br /><searchLink fieldCode="DE" term="%22Brazil%22">Brazil</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The influence of temperament traits on bipolar disorder (BD) has been investigated. Both temperament traits and BD are partially genetically determined and seem to be influenced by variations in the CACNA1C gene. These variations presented a significant interactive effect with biological sex, although studies that evaluate this relationship are scarce. Here, we assessed the mediation effect of temperament traits on the relationship between two polymorphisms in the CACNA1C gene (rs1006737 and rs4765913) and BD according to sex. This is a cross-sectional study consisting of 878 Caucasian individuals (508 women and 370 men), aged 18–35, enrolled in a population-based study in the city of Pelotas, Southern Brazil. BD diagnosis was evaluated using the clinical interview MINI 5.0, and temperament traits were assessed via the application of the Affective and Emotional Composite Temperament Scale (AFECTS). Mediation models were tested using the modeling tool PROCESS (version 3.3) for SPSS. Bootstrapping-enhanced mediation analyses in women indicated that traits anger (39%) and caution (27%) mediated the association between the rs4765913 SNP and BD, while traits volition (29%), anger (35%), and caution (29%) mediated the association between the AA haplotype (rs1006737–rs4765913) and the BD. No effect was encountered for cisgender men. Our model revealed that paths from CACNA1C SNPs to BD are mediated by specific temperament traits in women, reinforcing the definition of temperament traits as endophenotypes. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=162077176
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00406-022-01493-7
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 10
        StartPage: 41
    Subjects:
      – SubjectFull: Bipolar disorder
        Type: general
      – SubjectFull: Temperament
        Type: general
      – SubjectFull: Sex (Biology)
        Type: general
      – SubjectFull: Haplotypes
        Type: general
      – SubjectFull: Cisgender people
        Type: general
      – SubjectFull: Pelotas (Rio Grande do Sul, Brazil)
        Type: general
      – SubjectFull: Brazil
        Type: general
    Titles:
      – TitleFull: Temperament traits mediate the relationship between CACNA1C polymorphisms and bipolar disorder in cisgender women.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Bastos, Clarissa Ribeiro
      – PersonEntity:
          Name:
            NameFull: Bock, Bertha Bueno
      – PersonEntity:
          Name:
            NameFull: Xavier, Janaina
      – PersonEntity:
          Name:
            NameFull: Camerini, Laísa
      – PersonEntity:
          Name:
            NameFull: Dewes, Samantha Seibt
      – PersonEntity:
          Name:
            NameFull: Grellert, Mateus
      – PersonEntity:
          Name:
            NameFull: de Carvalho, Hudson Wander
      – PersonEntity:
          Name:
            NameFull: Jansen, Karen
      – PersonEntity:
          Name:
            NameFull: da Silva, Ricardo Azevedo
      – PersonEntity:
          Name:
            NameFull: Pinheiro, Ricardo Tavares
      – PersonEntity:
          Name:
            NameFull: de Mattos Souza, Luciano
      – PersonEntity:
          Name:
            NameFull: Oses, Jean Pierre
      – PersonEntity:
          Name:
            NameFull: Portela, Luis Valmor
      – PersonEntity:
          Name:
            NameFull: Lara, Diogo Rizzato
      – PersonEntity:
          Name:
            NameFull: Tovo-Rodrigues, Luciana
      – PersonEntity:
          Name:
            NameFull: Ghisleni, Gabriele
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Text: Feb2023
              Type: published
              Y: 2023
          Identifiers:
            – Type: issn-print
              Value: 09401334
          Numbering:
            – Type: volume
              Value: 273
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: European Archives of Psychiatry & Clinical Neuroscience
              Type: main
ResultId 1