View in EDS

Neural dynamics underlying associative learning in the dorsal and ventral hippocampus.

Saved in:
Bibliographic Details
Title: Neural dynamics underlying associative learning in the dorsal and ventral hippocampus.
Authors: Biane, Jeremy S. (AUTHOR), Ladow, Max A. (AUTHOR), Stefanini, Fabio (AUTHOR), Boddu, Sayi P. (AUTHOR), Fan, Austin (AUTHOR), Hassan, Shazreh (AUTHOR), Dundar, Naz (AUTHOR), Apodaca-Montano, Daniel L. (AUTHOR), Zhou, Lexi Zichen (AUTHOR), Fayner, Varya (AUTHOR), Woods, Nicholas I. (AUTHOR), Kheirbek, Mazen A. (AUTHOR)
Source: Nature Neuroscience. May2023, Vol. 26 Issue 5, p798-809. 12p.
Abstract: Animals associate cues with outcomes and update these associations as new information is presented. This requires the hippocampus, yet how hippocampal neurons track changes in cue–outcome associations remains unclear. Using two-photon calcium imaging, we tracked the same dCA1 and vCA1 neurons across days to determine how responses evolve across phases of odor–outcome learning. Initially, odors elicited robust responses in dCA1, whereas, in vCA1, odor responses primarily emerged after learning and embedded information about the paired outcome. Population activity in both regions rapidly reorganized with learning and then stabilized, storing learned odor representations for days, even after extinction or pairing with a different outcome. Additionally, we found stable, robust signals across CA1 when mice anticipated outcomes under behavioral control but not when mice anticipated an inescapable aversive outcome. These results show how the hippocampus encodes, stores and updates learned associations and illuminates the unique contributions of dorsal and ventral hippocampus. By tracking the activity of CA1 neurons during associative learning, Biane, Ladow et al. reveal the distinct contribution of neurons along the dorsoventral axis of CA1 in the encoding and updating of task-related representations throughout learning. [ABSTRACT FROM AUTHOR]
Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Description
Abstract:Animals associate cues with outcomes and update these associations as new information is presented. This requires the hippocampus, yet how hippocampal neurons track changes in cue–outcome associations remains unclear. Using two-photon calcium imaging, we tracked the same dCA1 and vCA1 neurons across days to determine how responses evolve across phases of odor–outcome learning. Initially, odors elicited robust responses in dCA1, whereas, in vCA1, odor responses primarily emerged after learning and embedded information about the paired outcome. Population activity in both regions rapidly reorganized with learning and then stabilized, storing learned odor representations for days, even after extinction or pairing with a different outcome. Additionally, we found stable, robust signals across CA1 when mice anticipated outcomes under behavioral control but not when mice anticipated an inescapable aversive outcome. These results show how the hippocampus encodes, stores and updates learned associations and illuminates the unique contributions of dorsal and ventral hippocampus. By tracking the activity of CA1 neurons during associative learning, Biane, Ladow et al. reveal the distinct contribution of neurons along the dorsoventral axis of CA1 in the encoding and updating of task-related representations throughout learning. [ABSTRACT FROM AUTHOR]
ISSN:10976256
DOI:10.1038/s41593-023-01296-6