Distinctive alterations in the mesocorticolimbic circuits in various psychiatric disorders.
Saved in:
| Title: | Distinctive alterations in the mesocorticolimbic circuits in various psychiatric disorders. |
|---|---|
| Authors: | Nakamura, Yuko (AUTHOR), Ishida, Takuya (AUTHOR), Tanaka, Saori C. (AUTHOR), Mitsuyama, Yuki (AUTHOR), Yokoyama, Satoshi (AUTHOR), Shinzato, Hotaka (AUTHOR), Itai, Eri (AUTHOR), Okada, Go (AUTHOR), Kobayashi, Yuko (AUTHOR), Kawashima, Takahiko (AUTHOR), Miyata, Jun (AUTHOR), Yoshihara, Yujiro (AUTHOR), Takahashi, Hidehiko (AUTHOR), Aoki, Ryuta (AUTHOR), Nakamura, Motoaki (AUTHOR), Ota, Haruhisa (AUTHOR), Itahashi, Takashi (AUTHOR), Morita, Susumu (AUTHOR), Kawakami, Shintaro (AUTHOR), Abe, Osamu (AUTHOR) |
| Source: | Psychiatry & Clinical Neurosciences. Jun2023, Vol. 77 Issue 6, p345-354. 10p. 2 Diagrams, 2 Charts, 2 Graphs. |
| Subjects: | Mental illness, Functional magnetic resonance imaging, Autism spectrum disorders, Mental depression, Nucleus accumbens |
| Abstract: | Aim: Increasing evidence suggests that psychiatric disorders are linked to alterations in the mesocorticolimbic dopamine‐related circuits. However, the common and disease‐specific alterations remain to be examined in schizophrenia (SCZ), major depressive disorder (MDD), and autism spectrum disorder (ASD). Thus, this study aimed to examine common and disease‐specific features related to mesocorticolimbic circuits. Methods: This study included 555 participants from four institutes with five scanners: 140 individuals with SCZ (45.0% female), 127 individuals with MDD (44.9%), 119 individuals with ASD (15.1%), and 169 healthy controls (HC) (34.9%). All participants underwent resting‐state functional magnetic resonance imaging. A parametric empirical Bayes approach was adopted to compare estimated effective connectivity among groups. Intrinsic effective connectivity focusing on the mesocorticolimbic dopamine‐related circuits including the ventral tegmental area (VTA), shell and core parts of the nucleus accumbens (NAc), and medial prefrontal cortex (mPFC) were examined using a dynamic causal modeling analysis across these psychiatric disorders. Results: The excitatory shell‐to‐core connectivity was greater in all patients than in the HC group. The inhibitory shell‐to‐VTA and shell‐to‐mPFC connectivities were greater in the ASD group than in the HC, MDD, and SCZ groups. Furthermore, the VTA‐to‐core and VTA‐to‐shell connectivities were excitatory in the ASD group, while those connections were inhibitory in the HC, MDD, and SCZ groups. Conclusion: Impaired signaling in the mesocorticolimbic dopamine‐related circuits could be an underlying neuropathogenesis of various psychiatric disorders. These findings will improve the understanding of unique neural alternations of each disorder and will facilitate identification of effective therapeutic targets. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
|
Full text is not displayed to guests.
Login for full access.
|
|
| Abstract: | Aim: Increasing evidence suggests that psychiatric disorders are linked to alterations in the mesocorticolimbic dopamine‐related circuits. However, the common and disease‐specific alterations remain to be examined in schizophrenia (SCZ), major depressive disorder (MDD), and autism spectrum disorder (ASD). Thus, this study aimed to examine common and disease‐specific features related to mesocorticolimbic circuits. Methods: This study included 555 participants from four institutes with five scanners: 140 individuals with SCZ (45.0% female), 127 individuals with MDD (44.9%), 119 individuals with ASD (15.1%), and 169 healthy controls (HC) (34.9%). All participants underwent resting‐state functional magnetic resonance imaging. A parametric empirical Bayes approach was adopted to compare estimated effective connectivity among groups. Intrinsic effective connectivity focusing on the mesocorticolimbic dopamine‐related circuits including the ventral tegmental area (VTA), shell and core parts of the nucleus accumbens (NAc), and medial prefrontal cortex (mPFC) were examined using a dynamic causal modeling analysis across these psychiatric disorders. Results: The excitatory shell‐to‐core connectivity was greater in all patients than in the HC group. The inhibitory shell‐to‐VTA and shell‐to‐mPFC connectivities were greater in the ASD group than in the HC, MDD, and SCZ groups. Furthermore, the VTA‐to‐core and VTA‐to‐shell connectivities were excitatory in the ASD group, while those connections were inhibitory in the HC, MDD, and SCZ groups. Conclusion: Impaired signaling in the mesocorticolimbic dopamine‐related circuits could be an underlying neuropathogenesis of various psychiatric disorders. These findings will improve the understanding of unique neural alternations of each disorder and will facilitate identification of effective therapeutic targets. [ABSTRACT FROM AUTHOR] |
|---|---|
| ISSN: | 13231316 |
| DOI: | 10.1111/pcn.13542 |
