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Orbitofrontal cortex control of striatum leads economic decision-making.

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Title: Orbitofrontal cortex control of striatum leads economic decision-making.
Authors: Gore, Felicity (AUTHOR), Hernandez, Melissa (AUTHOR), Ramakrishnan, Charu (AUTHOR), Crow, Ailey K. (AUTHOR), Malenka, Robert C. (AUTHOR), Deisseroth, Karl (AUTHOR)
Source: Nature Neuroscience. Sep2023, Vol. 26 Issue 9, p1566-1574. 9p.
Abstract: Animals must continually evaluate stimuli in their environment to decide which opportunities to pursue, and in many cases these decisions can be understood in fundamentally economic terms. Although several brain regions have been individually implicated in these processes, the brain-wide mechanisms relating these regions in decision-making are unclear. Using an economic decision-making task adapted for rats, we find that neural activity in both of two connected brain regions, the ventrolateral orbitofrontal cortex (OFC) and the dorsomedial striatum (DMS), was required for economic decision-making. Relevant neural activity in both brain regions was strikingly similar, dominated by the spatial features of the decision-making process. However, the neural encoding of choice direction in OFC preceded that of DMS, and this temporal relationship was strongly correlated with choice accuracy. Furthermore, activity specifically in the OFC projection to the DMS was required for appropriate economic decision-making. These results demonstrate that choice information in the OFC is relayed to the DMS to lead accurate economic decision-making. The authors show that choice information is relayed from the ventrolateral orbitofrontal cortex to the dorsomedial striatum to lead accurate economic decision-making. [ABSTRACT FROM AUTHOR]
Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: <searchLink fieldCode="AR" term="%22Gore%2C+Felicity%22">Gore, Felicity</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hernandez%2C+Melissa%22">Hernandez, Melissa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ramakrishnan%2C+Charu%22">Ramakrishnan, Charu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Crow%2C+Ailey+K%2E%22">Crow, Ailey K.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Malenka%2C+Robert+C%2E%22">Malenka, Robert C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Deisseroth%2C+Karl%22">Deisseroth, Karl</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Nature+Neuroscience%22">Nature Neuroscience</searchLink>. Sep2023, Vol. 26 Issue 9, p1566-1574. 9p.
– Name: Abstract
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  Data: Animals must continually evaluate stimuli in their environment to decide which opportunities to pursue, and in many cases these decisions can be understood in fundamentally economic terms. Although several brain regions have been individually implicated in these processes, the brain-wide mechanisms relating these regions in decision-making are unclear. Using an economic decision-making task adapted for rats, we find that neural activity in both of two connected brain regions, the ventrolateral orbitofrontal cortex (OFC) and the dorsomedial striatum (DMS), was required for economic decision-making. Relevant neural activity in both brain regions was strikingly similar, dominated by the spatial features of the decision-making process. However, the neural encoding of choice direction in OFC preceded that of DMS, and this temporal relationship was strongly correlated with choice accuracy. Furthermore, activity specifically in the OFC projection to the DMS was required for appropriate economic decision-making. These results demonstrate that choice information in the OFC is relayed to the DMS to lead accurate economic decision-making. The authors show that choice information is relayed from the ventrolateral orbitofrontal cortex to the dorsomedial striatum to lead accurate economic decision-making. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1038/s41593-023-01409-1
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              Text: Sep2023
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