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Neuronal types in the mouse amygdala and their transcriptional response to fear conditioning.

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Title:	Neuronal types in the mouse amygdala and their transcriptional response to fear conditioning.
Authors:	Hochgerner, Hannah (AUTHOR), Singh, Shelly (AUTHOR), Tibi, Muhammad (AUTHOR), Lin, Zhige (AUTHOR), Skarbianskis, Niv (AUTHOR), Admati, Inbal (AUTHOR), Ophir, Osnat (AUTHOR), Reinhardt, Nuphar (AUTHOR), Netser, Shai (AUTHOR), Wagner, Shlomo (AUTHOR), Zeisel, Amit (AUTHOR)
Source:	Nature Neuroscience. Dec2023, Vol. 26 Issue 12, p2237-2249. 13p.
Abstract:	The amygdala is a brain region primarily associated with emotional response. The use of genetic markers and single-cell transcriptomics can provide insights into behavior-associated cell state changes. Here we present a detailed cell-type taxonomy of the adult mouse amygdala during fear learning and memory consolidation. We perform single-cell RNA sequencing on naïve and fear-conditioned mice, identify 130 neuronal cell types and validate their spatial distributions. A subset of all neuronal types is transcriptionally responsive to fear learning and memory retrieval. The activated engram cells upregulate activity-response genes and coordinate the expression of genes associated with neurite outgrowth, synaptic signaling, plasticity and development. We identify known and previously undescribed candidate genes responsive to fear learning. Our molecular atlas may be used to generate hypotheses to unveil the neuron types and neural circuits regulating the emotional component of learning and memory. The neuronal subtypes regulating the emotional component of learning and memory are not fully described. Here the authors provide a molecular atlas of the adult mouse amygdala and show the subsets of cells transcriptionally responsive to fear. [ABSTRACT FROM AUTHOR]
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Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	The amygdala is a brain region primarily associated with emotional response. The use of genetic markers and single-cell transcriptomics can provide insights into behavior-associated cell state changes. Here we present a detailed cell-type taxonomy of the adult mouse amygdala during fear learning and memory consolidation. We perform single-cell RNA sequencing on naïve and fear-conditioned mice, identify 130 neuronal cell types and validate their spatial distributions. A subset of all neuronal types is transcriptionally responsive to fear learning and memory retrieval. The activated engram cells upregulate activity-response genes and coordinate the expression of genes associated with neurite outgrowth, synaptic signaling, plasticity and development. We identify known and previously undescribed candidate genes responsive to fear learning. Our molecular atlas may be used to generate hypotheses to unveil the neuron types and neural circuits regulating the emotional component of learning and memory. The neuronal subtypes regulating the emotional component of learning and memory are not fully described. Here the authors provide a molecular atlas of the adult mouse amygdala and show the subsets of cells transcriptionally responsive to fear. [ABSTRACT FROM AUTHOR]
ISSN:	10976256
DOI:	10.1038/s41593-023-01469-3