Prognostic significance of nutritional indices in patients with head and neck squamous cell carcinoma treated with immune checkpoint inhibitors.
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| Title: | Prognostic significance of nutritional indices in patients with head and neck squamous cell carcinoma treated with immune checkpoint inhibitors. |
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| Authors: | Miyamoto, Noriyuki (AUTHOR), Takenaka, Yukinori (AUTHOR), Sudo, Takato (AUTHOR), Eguchi, Hirotaka (AUTHOR), Tanaka, Hidenori (AUTHOR), Fukusumi, Takahito (AUTHOR), Takemoto, Norihiko (AUTHOR), Suzuki, Motoyuki (AUTHOR), Inohara, Hidenori (AUTHOR) |
| Source: | Acta Oto-Laryngologica. Oct2023, Vol. 143 Issue 10, p925-930. 6p. |
| Subjects: | Nutritional assessment, Immune checkpoint inhibitors, Confidence intervals, Head & neck cancer, Retrospective studies, Geriatric nutrition, Cancer patients, Kaplan-Meier estimator, Descriptive statistics, Tumor markers, Body mass index, Progression-free survival, Prediction models, Squamous cell carcinoma, Overall survival, Proportional hazards models |
| Geographic Terms: | Japan |
| Abstract (English): | Although patients with head and neck squamous cell cancer (HNSCC) often show malnutrition, its effects on immune checkpoint inhibitor (ICI) treatment outcomes in these patients are unclear. To investigate the prognostic influence of nutritional indices in patients with HNSCC treated with ICIs and determine the optimal indices. This retrospective study included 106 patients with HNSCC treated with ICIs between 2017 and 2022. The prognostic influences of body mass index (BMI), geriatric nutritional risk index (GNRI), and prognostic nutritional index (PNI) on overall survival (OS) and progression-free survival (PFS) were analysed using the Kaplan–Meier method and Cox-regression models. The 1-year PFS rates in the groups with high and low BMI, GNRI, and PNI were, respectively, 24.2% and 28.4% (p =.731), 29.7% and 14.4% (p =.024), and 30.3% and 13.9% (p =.015). PNI was an independent prognostic factor for both PFS (hazard ratio (HR) = 1.89; 95% confidence interval (CI), 1.08–3.29) and OS (HR = 3.26; 95% CI, 1.66–6.40). PNI can predict ICI outcomes and should be assessed when ICI treatment is considered. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): | 背景: 尽管头颈鳞状细胞癌 (HNSCC) 患者经常表现出营养不良, 但是营养不良对这些患者的免疫检查点抑制剂(ICI)治疗结果的影响还不清楚。 目的: 探讨营养指数对接受ICI治疗的 HNSCC 患者预后的影响与并确定最佳指数。 方法: 这项回顾性研究纳入了 2017 年至 2022年期间接受 ICI 治疗的 106 例 HNSCC 患者。使用 Kaplan-Meier 方法和 Cox 回归模型分析了体重指数 (BMI)、老年营养风险指数 (GNRI) 和预后营养指数(PNI)对总生存期(OS)和无进展生存期(PFS)的影响。 结果: BMI、GNRI 和 PNI 高组和低组的 1 年 PFS 率分别为24.2% 和 28.4% (p =.731)、29.7% 和 14.4% (p =.024) 以及 30.3% 和 13.9% (p =.015)。 PNI 是 PFS(风险比 (HR) = 1.89；95% 置信区间 (CI), 1.08–3.29)和 OS(HR = 3.26；95% CI, 1.66–6.40)的独立预后因素。 结论: PNI 可以预测 ICI 结果, 在考虑 ICI 治疗时应对它进行评估。 [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Although patients with head and neck squamous cell cancer (HNSCC) often show malnutrition, its effects on immune checkpoint inhibitor (ICI) treatment outcomes in these patients are unclear. To investigate the prognostic influence of nutritional indices in patients with HNSCC treated with ICIs and determine the optimal indices. This retrospective study included 106 patients with HNSCC treated with ICIs between 2017 and 2022. The prognostic influences of body mass index (BMI), geriatric nutritional risk index (GNRI), and prognostic nutritional index (PNI) on overall survival (OS) and progression-free survival (PFS) were analysed using the Kaplan–Meier method and Cox-regression models. The 1-year PFS rates in the groups with high and low BMI, GNRI, and PNI were, respectively, 24.2% and 28.4% (p =.731), 29.7% and 14.4% (p =.024), and 30.3% and 13.9% (p =.015). PNI was an independent prognostic factor for both PFS (hazard ratio (HR) = 1.89; 95% confidence interval (CI), 1.08–3.29) and OS (HR = 3.26; 95% CI, 1.66–6.40). PNI can predict ICI outcomes and should be assessed when ICI treatment is considered. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00016489 |
| DOI: | 10.1080/00016489.2023.2288910 |
