Cannabidiol does not attenuate acute delta‐9‐tetrahydrocannabinol‐induced attentional bias in healthy volunteers: A randomised, double‐blind, cross‐over study.
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| Title: | Cannabidiol does not attenuate acute delta‐9‐tetrahydrocannabinol‐induced attentional bias in healthy volunteers: A randomised, double‐blind, cross‐over study. |
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| Authors: | Oliver, Dominic, Englund, Amir, Chesney, Edward, Chester, Lucy, Wilson, Jack, Sovi, Simina, Wigroth, Stina, Hodsoll, John, Strang, John, Murray, Robin M., Freeman, Tom P., Fusar‐Poli, Paolo, McGuire, Philip |
| Source: | Addiction. Feb2024, Vol. 119 Issue 2, p322-333. 12p. |
| Subjects: | Cannabidiol, Substance abuse, Cannabis (Genus), Confidence intervals, Hydrocarbons, Randomized controlled trials, Blind experiment, Descriptive statistics, Research funding, Data analysis software, Odds ratio, Attentional bias |
| Abstract: | Aims: To test how attentional bias and explicit liking are influenced by delta‐9‐tetrahydrocannabinol (THC) and whether these effects are moderated by cannabidiol (CBD). Design: Double‐blind, randomised, within‐subjects cross‐over study. Setting NIHR Wellcome Trust Clinical Research Facility at King's College Hospital, London, United Kingdom. Participants/Cases: Forty‐six infrequent cannabis users (cannabis use <1 per week). Intervention(s): Across four sessions, participants inhaled vaporised cannabis containing 10 mg of THC and either 0 mg (0:1 CBD:THC), 10 mg (1:1), 20 mg (2:1) or 30 mg (3:1) of CBD, administered in a randomised order and counter‐balanced across participants (a total of 24 order groups). Measurements Participants completed two tasks: (1) Attentional Bias (AB), comparing reaction times toward visual probes presented behind 28 target stimuli (cannabis/food) compared with probes behind corresponding non‐target (neutral) stimuli. Participants responding more quickly to probes behind target than non‐target stimuli would indicate greater attentional bias to cannabis/food; (2) Picture Rating (PR), where all AB stimuli were rated on a 7‐point pleasantness scale, measuring explicit liking. Findings During the AB task, participants were more biased toward cannabis stimuli in the 0:1 condition compared with baseline (mean difference = 12.2, 95% confidence intervals [CIs] = 1.20–23.3, d = 0.41, P = 0.03). No other significant AB or PR differences were found between cannabis and food stimuli between baseline and 0:1 condition (P > 0.05). No significant CBD effect was found on AB or PR task performance at any dose (P > 0.05). There was additionally no cumulative effect of THC exposure on AB or PR outcomes (P > 0.05). Conclusions: A double‐blind, randomised, cross‐over study among infrequent cannabis users found that inhaled delta‐9‐tetrahydrocannabinol increased attentional bias toward cannabis in the absence of explicit liking, a marker of liability toward cannabis use disorder. At the concentrations normally found in legal and illegal cannabis, cannabidiol had no influence on this effect. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Aims: To test how attentional bias and explicit liking are influenced by delta‐9‐tetrahydrocannabinol (THC) and whether these effects are moderated by cannabidiol (CBD). Design: Double‐blind, randomised, within‐subjects cross‐over study. Setting NIHR Wellcome Trust Clinical Research Facility at King's College Hospital, London, United Kingdom. Participants/Cases: Forty‐six infrequent cannabis users (cannabis use <1 per week). Intervention(s): Across four sessions, participants inhaled vaporised cannabis containing 10 mg of THC and either 0 mg (0:1 CBD:THC), 10 mg (1:1), 20 mg (2:1) or 30 mg (3:1) of CBD, administered in a randomised order and counter‐balanced across participants (a total of 24 order groups). Measurements Participants completed two tasks: (1) Attentional Bias (AB), comparing reaction times toward visual probes presented behind 28 target stimuli (cannabis/food) compared with probes behind corresponding non‐target (neutral) stimuli. Participants responding more quickly to probes behind target than non‐target stimuli would indicate greater attentional bias to cannabis/food; (2) Picture Rating (PR), where all AB stimuli were rated on a 7‐point pleasantness scale, measuring explicit liking. Findings During the AB task, participants were more biased toward cannabis stimuli in the 0:1 condition compared with baseline (mean difference = 12.2, 95% confidence intervals [CIs] = 1.20–23.3, d = 0.41, P = 0.03). No other significant AB or PR differences were found between cannabis and food stimuli between baseline and 0:1 condition (P > 0.05). No significant CBD effect was found on AB or PR task performance at any dose (P > 0.05). There was additionally no cumulative effect of THC exposure on AB or PR outcomes (P > 0.05). Conclusions: A double‐blind, randomised, cross‐over study among infrequent cannabis users found that inhaled delta‐9‐tetrahydrocannabinol increased attentional bias toward cannabis in the absence of explicit liking, a marker of liability toward cannabis use disorder. At the concentrations normally found in legal and illegal cannabis, cannabidiol had no influence on this effect. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 09652140 |
| DOI: | 10.1111/add.16353 |
