Comparing family‐based treatment with inpatient treatment in youth with anorexia nervosa eligible for hospitalization: A 12‐month feasibility study.
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| Title: | Comparing family‐based treatment with inpatient treatment in youth with anorexia nervosa eligible for hospitalization: A 12‐month feasibility study. |
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| Authors: | Haas, Verena, Wechsung, Katja, Kaiser, Vivien, Schmidt, Janine, Raile, Klemens, Busjahn, Andreas, Le Grange, Daniel, Correll, Christoph U. |
| Source: | International Journal of Eating Disorders. Feb2024, Vol. 57 Issue 2, p388-399. 12p. |
| Subjects: | Anorexia nervosa treatment, Family psychotherapy, Pilot projects, Length of stay in hospitals, Professional practice, Suicide, Clinical trials, Burden of care, Evidence-based medicine, Mann Whitney U Test, Fisher exact test, Treatment effectiveness, Comparative studies, Weight gain, T-test (Statistics), Psychological tests, Hospital care, Research funding, Pathological psychology, Questionnaires, Repeated measures design, Descriptive statistics, Cost effectiveness, Body mass index, Adverse health care events, Data analysis software, Statistical models, Outpatient services in hospitals, Longitudinal method, Self-mutilation, Adolescence |
| Geographic Terms: | Germany |
| Abstract: | Objective: Family‐based treatment (FBT) for youth with anorexia nervosa (AN), has not been compared to inpatient, multimodal treatment (IMT). Method: Prospective, non‐randomized pilot feasibility study of adolescents with AN receiving FBT (n = 31), and as a reference point for exploratory outcome comparisons IMT (n = 31), matched for baseline age and percent median BMI (%mBMI). Feasibility of FBT in youth fulfilling criteria for IMT was assessed via study recruitment and retention rates; acceptability via drop‐out and caregiver strain; safety via adverse events; preliminary treatment effectiveness between groups was assessed via a change in %mBMI, AN psychopathology (Eating Disorder Examination‐Questionnaire, EDE‐Q), and hospital days, over 12 months with intent‐to‐treat, mixed models repeated measures analyses covering post‐intervention usual care until 12 months. Results: Taking into account that 8 FBT patients (25.8%) crossed over to IMT due to lack of weight gain or psychiatric concerns, FBT and IMT were similarly feasible, acceptable, and safe, apart from more physical antagonism toward others in FBT (p =.010). FBT lasted longer (median [interquartile range, IQR]; 33.6 [17.4, 49.9] vs. 17.3 [14.4, 24] weeks, p <.001), but required fewer hospital days than IMT (median, [IQR], FBT = 1 [0, 16] vs. IMT = 123 [101, 180], p <.001). Baseline comorbidity‐adjusted changes over 12 months did not differ between groups in %mBMI (FBT = 12.6 ± 11.9 vs. IMT = 13.7 ± 9.1; p =.702) and EDE‐Q global score (median, [IQR]; FBT = −1.2 [−2.3, 0.2] vs. IMT = −1.3 [−2.8, −0.4]; p =.733). Discussion: Implementing FBT in this pilot study was feasible, acceptable, and safe for youth eligible for IMT according to German S3 guidelines. Non‐inferiority of FBT versus IMT requires confirmation in a sufficiently large multicenter RCT. Public Significance: This pilot study with 62 adolescent patients with anorexia nervosa demonstrated that for 2/3rd of patients eligible for a long hospitalization in the German health care system, outpatient, Family‐based treatment (FBT) was a safe and feasible treatment alternative. Over 12 months, FBT lead to similar weight gain and reduction in eating disorder cognitions as inpatient treatment with fewer hospital days. This pilot study needs to be followed up by a larger, multicenter trial. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Objective: Family‐based treatment (FBT) for youth with anorexia nervosa (AN), has not been compared to inpatient, multimodal treatment (IMT). Method: Prospective, non‐randomized pilot feasibility study of adolescents with AN receiving FBT (n = 31), and as a reference point for exploratory outcome comparisons IMT (n = 31), matched for baseline age and percent median BMI (%mBMI). Feasibility of FBT in youth fulfilling criteria for IMT was assessed via study recruitment and retention rates; acceptability via drop‐out and caregiver strain; safety via adverse events; preliminary treatment effectiveness between groups was assessed via a change in %mBMI, AN psychopathology (Eating Disorder Examination‐Questionnaire, EDE‐Q), and hospital days, over 12 months with intent‐to‐treat, mixed models repeated measures analyses covering post‐intervention usual care until 12 months. Results: Taking into account that 8 FBT patients (25.8%) crossed over to IMT due to lack of weight gain or psychiatric concerns, FBT and IMT were similarly feasible, acceptable, and safe, apart from more physical antagonism toward others in FBT (p =.010). FBT lasted longer (median [interquartile range, IQR]; 33.6 [17.4, 49.9] vs. 17.3 [14.4, 24] weeks, p <.001), but required fewer hospital days than IMT (median, [IQR], FBT = 1 [0, 16] vs. IMT = 123 [101, 180], p <.001). Baseline comorbidity‐adjusted changes over 12 months did not differ between groups in %mBMI (FBT = 12.6 ± 11.9 vs. IMT = 13.7 ± 9.1; p =.702) and EDE‐Q global score (median, [IQR]; FBT = −1.2 [−2.3, 0.2] vs. IMT = −1.3 [−2.8, −0.4]; p =.733). Discussion: Implementing FBT in this pilot study was feasible, acceptable, and safe for youth eligible for IMT according to German S3 guidelines. Non‐inferiority of FBT versus IMT requires confirmation in a sufficiently large multicenter RCT. Public Significance: This pilot study with 62 adolescent patients with anorexia nervosa demonstrated that for 2/3rd of patients eligible for a long hospitalization in the German health care system, outpatient, Family‐based treatment (FBT) was a safe and feasible treatment alternative. Over 12 months, FBT lead to similar weight gain and reduction in eating disorder cognitions as inpatient treatment with fewer hospital days. This pilot study needs to be followed up by a larger, multicenter trial. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 02763478 |
| DOI: | 10.1002/eat.24098 |
