Restarting smoking after discharge from clozapine inpatient initiation: Elevated rehospitalization rates smoking & clozapine rehospitalization.

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Title: Restarting smoking after discharge from clozapine inpatient initiation: Elevated rehospitalization rates smoking & clozapine rehospitalization.
Authors: So, Ryuhei (AUTHOR), Tsukahara, Masaru (AUTHOR), Nakajima, Shinichiro (AUTHOR), Takeuchi, Hiroyoshi (AUTHOR)
Source: Psychiatry & Clinical Neurosciences. Apr2024, Vol. 78 Issue 4, p259-260. 2p.
Subjects: Clozapine, Patient readmissions, Smoking statistics
Abstract: This article discusses the impact of smoking on relapse rates in patients with treatment-resistant schizophrenia (TRS) who are taking clozapine, a medication commonly used to treat TRS. The study was conducted in Japan, where a smoking ban was implemented in psychiatric hospitals. The researchers found that patients who resumed smoking after discharge had a higher risk of rehospitalization compared to those who did not smoke. These findings suggest that clinicians should consider measuring clozapine blood concentrations before and after discharge, especially in smokers, and adjust the clozapine dose accordingly. Further research is needed to validate these findings and develop clinical guidelines for monitoring and adjusting clozapine doses. [Extracted from the article]
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Database: Psychology and Behavioral Sciences Collection
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Abstract:This article discusses the impact of smoking on relapse rates in patients with treatment-resistant schizophrenia (TRS) who are taking clozapine, a medication commonly used to treat TRS. The study was conducted in Japan, where a smoking ban was implemented in psychiatric hospitals. The researchers found that patients who resumed smoking after discharge had a higher risk of rehospitalization compared to those who did not smoke. These findings suggest that clinicians should consider measuring clozapine blood concentrations before and after discharge, especially in smokers, and adjust the clozapine dose accordingly. Further research is needed to validate these findings and develop clinical guidelines for monitoring and adjusting clozapine doses. [Extracted from the article]
ISSN:13231316
DOI:10.1111/pcn.13629