Free-viewing gaze patterns reveal a mood-congruency bias in MDD during an affective fMRI/eye-tracking task.
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| Title: | Free-viewing gaze patterns reveal a mood-congruency bias in MDD during an affective fMRI/eye-tracking task. |
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| Authors: | Sun, Rui (AUTHOR), Fietz, Julia (AUTHOR), Erhart, Mira (AUTHOR), Poehlchen, Dorothee (AUTHOR), Henco, Lara (AUTHOR), Brückl, Tanja M. (AUTHOR), Binder, Elisabeth B. (AUTHOR), Erhardt, Angelika (AUTHOR), Lucae, Susanne (AUTHOR), Grandi, Norma C. (AUTHOR), Namendorf, Tamara (AUTHOR), Elbau, Immanuel (AUTHOR), Leuchs, Laura (AUTHOR), Brem, Anna Katharine (AUTHOR), Schilbach, Leonhard (AUTHOR), Ilić-Ćoćić, Sanja (AUTHOR), Ziebula, Julius (AUTHOR), von Mücke-Heim, Iven-Alex (AUTHOR), Kim, Yeho (AUTHOR), Pape, Julius (AUTHOR) |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. Apr2024, Vol. 274 Issue 3, p559-571. 13p. |
| Subjects: | Attentional bias, Mental depression, Gaze, Affect (Psychology), Face perception, Pathological psychology |
| Geographic Terms: | Munich (Germany) |
| Abstract: | Major depressive disorder (MDD) has been related to abnormal amygdala activity during emotional face processing. However, a recent large-scale study (n = 28,638) found no such correlation, which is probably due to the low precision of fMRI measurements. To address this issue, we used simultaneous fMRI and eye-tracking measurements during a commonly employed emotional face recognition task. Eye-tracking provide high-precision data, which can be used to enrich and potentially stabilize fMRI readouts. With the behavioral response, we additionally divided the active task period into a task-related and a free-viewing phase to explore the gaze patterns of MDD patients and healthy controls (HC) and compare their respective neural correlates. Our analysis showed that a mood-congruency attentional bias could be detected in MDD compared to healthy controls during the free-viewing phase but without parallel amygdala disruption. Moreover, the neural correlates of gaze patterns reflected more prefrontal fMRI activity in the free-viewing than the task-related phase. Taken together, spontaneous emotional processing in free viewing might lead to a more pronounced mood-congruency bias in MDD, which indicates that combined fMRI with eye-tracking measurement could be beneficial for our understanding of the underlying psychopathology of MDD in different emotional processing phases. Trial Registration: The BeCOME study is registered on ClinicalTrials (gov: NCT03984084) by the Max Planck Institute of Psychiatry in Munich, Germany. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Major depressive disorder (MDD) has been related to abnormal amygdala activity during emotional face processing. However, a recent large-scale study (n = 28,638) found no such correlation, which is probably due to the low precision of fMRI measurements. To address this issue, we used simultaneous fMRI and eye-tracking measurements during a commonly employed emotional face recognition task. Eye-tracking provide high-precision data, which can be used to enrich and potentially stabilize fMRI readouts. With the behavioral response, we additionally divided the active task period into a task-related and a free-viewing phase to explore the gaze patterns of MDD patients and healthy controls (HC) and compare their respective neural correlates. Our analysis showed that a mood-congruency attentional bias could be detected in MDD compared to healthy controls during the free-viewing phase but without parallel amygdala disruption. Moreover, the neural correlates of gaze patterns reflected more prefrontal fMRI activity in the free-viewing than the task-related phase. Taken together, spontaneous emotional processing in free viewing might lead to a more pronounced mood-congruency bias in MDD, which indicates that combined fMRI with eye-tracking measurement could be beneficial for our understanding of the underlying psychopathology of MDD in different emotional processing phases. Trial Registration: The BeCOME study is registered on ClinicalTrials (gov: NCT03984084) by the Max Planck Institute of Psychiatry in Munich, Germany. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 09401334 |
| DOI: | 10.1007/s00406-023-01608-8 |
