Changes in hearing function and intracochlear morphology after electrode array insertion in minipigs.
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| Title: | Changes in hearing function and intracochlear morphology after electrode array insertion in minipigs. |
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| Authors: | Du, Haiqiao (AUTHOR), Li, Jianan (AUTHOR), Chen, Zhifeng (AUTHOR), Gao, Yun (AUTHOR), Yang, Xiao (AUTHOR), Yuan, Shuolong (AUTHOR), Wang, Qian (AUTHOR), Guo, Weiwei (AUTHOR), Chen, Wei (AUTHOR), Dai, Pu (AUTHOR), Yang, Shiming (AUTHOR) |
| Source: | Acta Oto-Laryngologica. Mar2024, Vol. 144 Issue 3, p159-167. 9p. |
| Subjects: | Cochlear implants, Biological models, Swine, Research funding, Artificial implants, Animal experimentation, Hearing, Electrodes |
| Abstract (English): | In temporal bone specimens from long-term cochlear implant users, foreign body response within the cochlea has been demonstrated. However, how hearing changes after implantation and fibrosis progresses within the cochlea is unknown. To investigate the short-term dynamic changes in hearing and cochlear histopathology in minipigs after electrode array insertion. Twelve minipigs were selected for electrode array insertion (EAI) and the Control. Hearing tests were performed preoperatively and on 0, 7, 14, and 28 day(s) postoperatively, and cochlear histopathology was performed after the hearing tests on 7, 14, and 28 days after surgery. Electrode array insertion had a significant effect for the frequency range tested (1 kHz–20kHz). Exudation was evident one week after electrode array insertion; at four weeks postoperatively, a fibrous sheath formed around the electrode. At each time point, the endolymphatic hydrops was found; no significant changes in the morphology and packing density of the spiral ganglion neurons were observed. The effect of electrode array insertion on hearing and intracochlear fibrosis was significant. The process of fibrosis and endolymphatic hydrops seemed to not correlate with the degree of hearing loss, nor did it affect spiral ganglion neuron integrity in the 4-week postoperative period. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): | 背景：在长期人工耳蜗植入者的颞骨标本中, 已发现耳蜗内异物反应。 然而, 植入后听力如何变化以及耳蜗内纤维化的发展尚不清楚。 目的：调查插入电极阵列后小型猪的听力和耳蜗组织病理学的短期动态变化。 材料和方法：选择 12 只小型猪进行电极阵列插入（EAI）和对照。 在术前以及术后 0、7、14 和 28 天进行听力测试, 并且在术后7、14、28天听力检查后进行耳蜗组织病理学检查。 结果：电极阵列插入对测试的频率范围 (1kHz–20kHz) 有着显著影响。电极阵列插入后一周有明显渗出； 术后4周, 电极周围形成纤维护套。 各时间点均发现内淋巴积水； 没有观察到螺旋神经节神经元的形态和堆积密度的显著变化。 结论及意义：电极阵列插入对听力和耳蜗内纤维化影响显著。 纤维化过程和内淋巴积水似乎与术后4周期间的听力损失程度无关, 也不影响螺旋神经节神经元的完整性。 [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | In temporal bone specimens from long-term cochlear implant users, foreign body response within the cochlea has been demonstrated. However, how hearing changes after implantation and fibrosis progresses within the cochlea is unknown. To investigate the short-term dynamic changes in hearing and cochlear histopathology in minipigs after electrode array insertion. Twelve minipigs were selected for electrode array insertion (EAI) and the Control. Hearing tests were performed preoperatively and on 0, 7, 14, and 28 day(s) postoperatively, and cochlear histopathology was performed after the hearing tests on 7, 14, and 28 days after surgery. Electrode array insertion had a significant effect for the frequency range tested (1 kHz–20kHz). Exudation was evident one week after electrode array insertion; at four weeks postoperatively, a fibrous sheath formed around the electrode. At each time point, the endolymphatic hydrops was found; no significant changes in the morphology and packing density of the spiral ganglion neurons were observed. The effect of electrode array insertion on hearing and intracochlear fibrosis was significant. The process of fibrosis and endolymphatic hydrops seemed to not correlate with the degree of hearing loss, nor did it affect spiral ganglion neuron integrity in the 4-week postoperative period. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00016489 |
| DOI: | 10.1080/00016489.2024.2341122 |
