Children with a history of both maternal immune activation and prematurity are not at increased risk of ADHD symptoms.
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| Title: | Children with a history of both maternal immune activation and prematurity are not at increased risk of ADHD symptoms. |
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| Authors: | Ellul, Pierre, Wallez, Solène, Acquaviva, Eric, Rosenzwajg, Michelle, Klatzmann, David, Delorme, Richard, Melchior, Maria |
| Source: | European Child & Adolescent Psychiatry. Jun2024, Vol. 33 Issue 6, p2001-2004. 4p. |
| Subjects: | Risk assessment, Cross-sectional method, Pearson correlation (Statistics), Attention-deficit hyperactivity disorder, Prenatal exposure delayed effects, Premature infants, Neural development, Logistic regression analysis, Descriptive statistics, Immunology, Multivariate analysis, Chi-squared test, Odds ratio, Longitudinal method, Autoimmune diseases, Child Behavior Checklist, Confidence intervals, Disease complications, Children |
| Abstract: | Maternal autoimmune diseases (AID) are risk factors for Attention Deficit Hyperactivity Disorder (ADHD). Animal studies suggest that maternal immune activation (MIA) is a disease primer for ADHD, with second environmental factor precipitating the onset of the disease. Prematurity is also a major risk factor for ADHD. In this study, we sought to explore the interaction between parental AID and prematurity on ADHD risk in a community sample. Children of AID parents born prematurely appeared at increased odds of ADHD but these two risk factors do not appear to be additive (OR 1.39 [95 CI 0.75; 2.46]). Longitudinal studies with larger numbers of participants are needed. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Maternal autoimmune diseases (AID) are risk factors for Attention Deficit Hyperactivity Disorder (ADHD). Animal studies suggest that maternal immune activation (MIA) is a disease primer for ADHD, with second environmental factor precipitating the onset of the disease. Prematurity is also a major risk factor for ADHD. In this study, we sought to explore the interaction between parental AID and prematurity on ADHD risk in a community sample. Children of AID parents born prematurely appeared at increased odds of ADHD but these two risk factors do not appear to be additive (OR 1.39 [95 CI 0.75; 2.46]). Longitudinal studies with larger numbers of participants are needed. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 10188827 |
| DOI: | 10.1007/s00787-023-02276-8 |
