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Electroacupuncture alleviates myocardial ischemia–reperfusion injury by inhibiting hypothalamic paraventricular nucleus neurons projecting to the rostral ventrolateral medulla.

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Title: Electroacupuncture alleviates myocardial ischemia–reperfusion injury by inhibiting hypothalamic paraventricular nucleus neurons projecting to the rostral ventrolateral medulla.
Authors: Shu, Qi (AUTHOR), Zhou, Jie (AUTHOR), Zhang, Bin (AUTHOR), Zhang, Fan (AUTHOR), Zhou, Xiang (AUTHOR), Wu, Yan (AUTHOR), Chang, Huimin (AUTHOR), Hu, Ling (AUTHOR), Cai, Ronglin (AUTHOR), Yu, Qing (AUTHOR)
Source: European Journal of Neuroscience. Sep2024, Vol. 60 Issue 5, p4861-4876. 16p.
Subjects: Neural pathways, Paraventricular nucleus, Lactate dehydrogenase, Treatment effectiveness, Creatine kinase
Abstract: Accumulating evidence suggests that electroacupuncture (EA) has obvious therapeutic effects and unique advantages in alleviating myocardial ischemia–reperfusion injury (MIRI), while the underlying neuromolecular mechanisms of EA intervention for MIRI have not been fully elucidated. The aim of the study is to investigate the role of the neural pathway of hypothalamic paraventricular nucleus (PVN) neurons projecting to the rostral ventrolateral medulla (RVLM) in the alleviation of MIRI rats by EA preconditioning. MIRI models were established by ligating the left anterior descending coronary artery for 30 min followed by reperfusion for 2 h. Electrocardiogram recording, chemogenetics, enzyme‐linked immunosorbent assay, multichannel physiology recording and haematoxylin–eosin and immunofluorescence staining methods were conducted to demonstrate that the firing frequencies of neurons in the PVN and the expression of c‐Fos decreased by EA pretreatment. Meanwhile, EA preconditioning significantly reduced the levels of creatine kinase isoenzymes (CK‐MB), cardiac troponin I (cTnI) and lactic dehydrogenase (LDH). Virus tracing showed a projection connection between PVN and RVLM. The inhibition of the PVN‐RVLM neural pathway could replicate the protective effect of EA pretreatment on MIRI rats. However, the activation of the pathway weakened the effect of EA preconditioning. EA pretreatment alleviated MIRI by regulating PVN neurons projecting to RVLM. This work provides novel evidence of EA pretreatment for alleviating MIRI. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Electroacupuncture alleviates myocardial ischemia–reperfusion injury by inhibiting hypothalamic paraventricular nucleus neurons projecting to the rostral ventrolateral medulla.
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  Data: <searchLink fieldCode="AR" term="%22Shu%2C+Qi%22">Shu, Qi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhou%2C+Jie%22">Zhou, Jie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Bin%22">Zhang, Bin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Fan%22">Zhang, Fan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhou%2C+Xiang%22">Zhou, Xiang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Yan%22">Wu, Yan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chang%2C+Huimin%22">Chang, Huimin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hu%2C+Ling%22">Hu, Ling</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cai%2C+Ronglin%22">Cai, Ronglin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yu%2C+Qing%22">Yu, Qing</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Sep2024, Vol. 60 Issue 5, p4861-4876. 16p.
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  Data: <searchLink fieldCode="DE" term="%22Neural+pathways%22">Neural pathways</searchLink><br /><searchLink fieldCode="DE" term="%22Paraventricular+nucleus%22">Paraventricular nucleus</searchLink><br /><searchLink fieldCode="DE" term="%22Lactate+dehydrogenase%22">Lactate dehydrogenase</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Creatine+kinase%22">Creatine kinase</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Accumulating evidence suggests that electroacupuncture (EA) has obvious therapeutic effects and unique advantages in alleviating myocardial ischemia–reperfusion injury (MIRI), while the underlying neuromolecular mechanisms of EA intervention for MIRI have not been fully elucidated. The aim of the study is to investigate the role of the neural pathway of hypothalamic paraventricular nucleus (PVN) neurons projecting to the rostral ventrolateral medulla (RVLM) in the alleviation of MIRI rats by EA preconditioning. MIRI models were established by ligating the left anterior descending coronary artery for 30 min followed by reperfusion for 2 h. Electrocardiogram recording, chemogenetics, enzyme‐linked immunosorbent assay, multichannel physiology recording and haematoxylin–eosin and immunofluorescence staining methods were conducted to demonstrate that the firing frequencies of neurons in the PVN and the expression of c‐Fos decreased by EA pretreatment. Meanwhile, EA preconditioning significantly reduced the levels of creatine kinase isoenzymes (CK‐MB), cardiac troponin I (cTnI) and lactic dehydrogenase (LDH). Virus tracing showed a projection connection between PVN and RVLM. The inhibition of the PVN‐RVLM neural pathway could replicate the protective effect of EA pretreatment on MIRI rats. However, the activation of the pathway weakened the effect of EA preconditioning. EA pretreatment alleviated MIRI by regulating PVN neurons projecting to RVLM. This work provides novel evidence of EA pretreatment for alleviating MIRI. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/ejn.16480
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        Text: English
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      – SubjectFull: Neural pathways
        Type: general
      – SubjectFull: Paraventricular nucleus
        Type: general
      – SubjectFull: Lactate dehydrogenase
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      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Creatine kinase
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    Titles:
      – TitleFull: Electroacupuncture alleviates myocardial ischemia–reperfusion injury by inhibiting hypothalamic paraventricular nucleus neurons projecting to the rostral ventrolateral medulla.
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            – D: 01
              M: 09
              Text: Sep2024
              Type: published
              Y: 2024
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