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Coupling antigens from multiple subtypes of influenza can broaden antibody and T cell responses.

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Title: Coupling antigens from multiple subtypes of influenza can broaden antibody and T cell responses.
Authors: Mallajosyula, Vamsee, Chakraborty, Saborni, Sola, Elsa, Fong, Ryan Furuichi, Shankar, Vishnu, Fei Gao, Burrell, Allison R., Gupta, Neha, Wagar, Lisa E., Mischel, Paul S., Capasso, Robson, Staat, Mary A., Yueh-Hsiu Chien, Dekker, Cornelia L., Wang, Taia T., Davis, Mark M.
Source: Science (pre-March 2025). 12/20/2024, Vol. 386 Issue 6728, p1389-1395. 7p. 4 Color Photographs.
Subjects: Influenza, T cells, Avian influenza, Seasonal influenza, Monozygotic twins, Antigens
Abstract: The seasonal influenza vaccine contains strains of viruses from distinct subtypes that are grown independently and then combined. However, most individuals exhibit a more robust response to one of these strains and thus are vulnerable to infection by others. By studying a monozygotic twin cohort, we found that although prior exposure is a factor, host genetics are a stronger driver of subtype bias to influenza viral strains. We found that covalent coupling of heterologous hemagglutinin (HA) from different viral strains could largely eliminate subtype bias in an animal model and in a human tonsil organoid system. We proposed that coupling of heterologous antigens improves antibody responses across influenza strains by broadening T cell help, and we found that using this approach substantially improved the antibody response to avian influenza HA. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Coupling antigens from multiple subtypes of influenza can broaden antibody and T cell responses.
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  Data: <searchLink fieldCode="AR" term="%22Mallajosyula%2C+Vamsee%22">Mallajosyula, Vamsee</searchLink><br /><searchLink fieldCode="AR" term="%22Chakraborty%2C+Saborni%22">Chakraborty, Saborni</searchLink><br /><searchLink fieldCode="AR" term="%22Sola%2C+Elsa%22">Sola, Elsa</searchLink><br /><searchLink fieldCode="AR" term="%22Fong%2C+Ryan+Furuichi%22">Fong, Ryan Furuichi</searchLink><br /><searchLink fieldCode="AR" term="%22Shankar%2C+Vishnu%22">Shankar, Vishnu</searchLink><br /><searchLink fieldCode="AR" term="%22Fei+Gao%22">Fei Gao</searchLink><br /><searchLink fieldCode="AR" term="%22Burrell%2C+Allison+R%2E%22">Burrell, Allison R.</searchLink><br /><searchLink fieldCode="AR" term="%22Gupta%2C+Neha%22">Gupta, Neha</searchLink><br /><searchLink fieldCode="AR" term="%22Wagar%2C+Lisa+E%2E%22">Wagar, Lisa E.</searchLink><br /><searchLink fieldCode="AR" term="%22Mischel%2C+Paul+S%2E%22">Mischel, Paul S.</searchLink><br /><searchLink fieldCode="AR" term="%22Capasso%2C+Robson%22">Capasso, Robson</searchLink><br /><searchLink fieldCode="AR" term="%22Staat%2C+Mary+A%2E%22">Staat, Mary A.</searchLink><br /><searchLink fieldCode="AR" term="%22Yueh-Hsiu+Chien%22">Yueh-Hsiu Chien</searchLink><br /><searchLink fieldCode="AR" term="%22Dekker%2C+Cornelia+L%2E%22">Dekker, Cornelia L.</searchLink><br /><searchLink fieldCode="AR" term="%22Wang%2C+Taia+T%2E%22">Wang, Taia T.</searchLink><br /><searchLink fieldCode="AR" term="%22Davis%2C+Mark+M%2E%22">Davis, Mark M.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 12/20/2024, Vol. 386 Issue 6728, p1389-1395. 7p. 4 Color Photographs.
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  Data: <searchLink fieldCode="DE" term="%22Influenza%22">Influenza</searchLink><br /><searchLink fieldCode="DE" term="%22T+cells%22">T cells</searchLink><br /><searchLink fieldCode="DE" term="%22Avian+influenza%22">Avian influenza</searchLink><br /><searchLink fieldCode="DE" term="%22Seasonal+influenza%22">Seasonal influenza</searchLink><br /><searchLink fieldCode="DE" term="%22Monozygotic+twins%22">Monozygotic twins</searchLink><br /><searchLink fieldCode="DE" term="%22Antigens%22">Antigens</searchLink>
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  Data: The seasonal influenza vaccine contains strains of viruses from distinct subtypes that are grown independently and then combined. However, most individuals exhibit a more robust response to one of these strains and thus are vulnerable to infection by others. By studying a monozygotic twin cohort, we found that although prior exposure is a factor, host genetics are a stronger driver of subtype bias to influenza viral strains. We found that covalent coupling of heterologous hemagglutinin (HA) from different viral strains could largely eliminate subtype bias in an animal model and in a human tonsil organoid system. We proposed that coupling of heterologous antigens improves antibody responses across influenza strains by broadening T cell help, and we found that using this approach substantially improved the antibody response to avian influenza HA. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=181793063
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        Value: 10.1126/science.adi2396
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        Text: English
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        PageCount: 7
        StartPage: 1389
    Subjects:
      – SubjectFull: Influenza
        Type: general
      – SubjectFull: T cells
        Type: general
      – SubjectFull: Avian influenza
        Type: general
      – SubjectFull: Seasonal influenza
        Type: general
      – SubjectFull: Monozygotic twins
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      – SubjectFull: Antigens
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      – TitleFull: Coupling antigens from multiple subtypes of influenza can broaden antibody and T cell responses.
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              Text: 12/20/2024
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