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Functional network disruptions in youth with concussion using the Adolescent Brain Cognitive Development study.

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Title: Functional network disruptions in youth with concussion using the Adolescent Brain Cognitive Development study.
Authors: Sheldrake, Elena, Nishat, Eman, Wheeler, Anne L., Goldstein, Benjamin I., Reed, Nick, Scratch, Shannon E.
Source: Brain Injury. 2025, Vol. 39 Issue 3, p199-210. 12p.
Subjects: Brain physiology, Amygdaloid body physiology, Functional connectivity, Treatment effectiveness, Anxiety, Magnetic resonance imaging, Default mode network, Internalizing behavior, Large-scale brain networks, Child Behavior Checklist, Neuroradiology, Brain concussion, Relaxation for health
Abstract: Objective: This study aimed to compare psychosocial outcomes and functional neuroimaging among youth with concussion, youth with anxiety, and age- and sex-matched controls. Methods: Using archival data from the Adolescent Brain Cognitive DevelopmentSM Study, we analyzed between-group differences in psychosocial outcomes measured by the Child Behavior Checklist's internalizing and externalizing problem scales, and assessed brain function using resting-state fMRI network-region connectivity (specifically frontoparietal network (FPN) and default mode network (DMN) connectivity with the amygdala). Results: Significant differences in psychosocial outcomes were found across all groups, with the anxiety group reporting the most internalizing problems, followed by the concussion group which significantly differed from controls. Additionally, FPN-amygdala connectivity was significantly reduced in the concussion group only; this reduced connectivity did not predict psychosocial outcomes across groups. Conclusion: This study provided preliminary findings that brain connectivity is reduced exclusively in individuals with concussion. Although disruptions were observed in the concussion group, further investigation is warranted to understand how disruptions may be associated with concussion symptoms. Studies that utilize well-defined control and study groups, and comprehensive cognitive and mental health measures will offer a deeper understanding of the relationship between brain function and psychosocial outcomes. [ABSTRACT FROM AUTHOR]
Copyright of Brain Injury is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Functional network disruptions in youth with concussion using the Adolescent Brain Cognitive Development study.
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  Data: Objective: This study aimed to compare psychosocial outcomes and functional neuroimaging among youth with concussion, youth with anxiety, and age- and sex-matched controls. Methods: Using archival data from the Adolescent Brain Cognitive DevelopmentSM Study, we analyzed between-group differences in psychosocial outcomes measured by the Child Behavior Checklist's internalizing and externalizing problem scales, and assessed brain function using resting-state fMRI network-region connectivity (specifically frontoparietal network (FPN) and default mode network (DMN) connectivity with the amygdala). Results: Significant differences in psychosocial outcomes were found across all groups, with the anxiety group reporting the most internalizing problems, followed by the concussion group which significantly differed from controls. Additionally, FPN-amygdala connectivity was significantly reduced in the concussion group only; this reduced connectivity did not predict psychosocial outcomes across groups. Conclusion: This study provided preliminary findings that brain connectivity is reduced exclusively in individuals with concussion. Although disruptions were observed in the concussion group, further investigation is warranted to understand how disruptions may be associated with concussion symptoms. Studies that utilize well-defined control and study groups, and comprehensive cognitive and mental health measures will offer a deeper understanding of the relationship between brain function and psychosocial outcomes. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Brain Injury is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1080/02699052.2024.2416545
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 12
        StartPage: 199
    Subjects:
      – SubjectFull: Brain physiology
        Type: general
      – SubjectFull: Amygdaloid body physiology
        Type: general
      – SubjectFull: Functional connectivity
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Anxiety
        Type: general
      – SubjectFull: Magnetic resonance imaging
        Type: general
      – SubjectFull: Default mode network
        Type: general
      – SubjectFull: Internalizing behavior
        Type: general
      – SubjectFull: Large-scale brain networks
        Type: general
      – SubjectFull: Child Behavior Checklist
        Type: general
      – SubjectFull: Neuroradiology
        Type: general
      – SubjectFull: Brain concussion
        Type: general
      – SubjectFull: Relaxation for health
        Type: general
    Titles:
      – TitleFull: Functional network disruptions in youth with concussion using the Adolescent Brain Cognitive Development study.
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            NameFull: Nishat, Eman
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              M: 02
              Text: 2025
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              Y: 2025
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