Associations of Education Attainment With Postpartum Depression and the Mediating Exploration: A Mendelian Randomization Study.
Saved in:
| Title: | Associations of Education Attainment With Postpartum Depression and the Mediating Exploration: A Mendelian Randomization Study. |
|---|---|
| Authors: | Wang, Xuanping (AUTHOR), Zhou, Fang-Yue (AUTHOR), Hao, Yanhui (AUTHOR), Wu, Jiaying (AUTHOR), Su, Kaizhen (AUTHOR), Chen, Si-Yue (AUTHOR), Yu, Wen (AUTHOR), Zhang, Chen (AUTHOR), Wu, Yan-Ting (AUTHOR), Huang, He-Feng (AUTHOR), Stoyanov, Drozdstoy (AUTHOR) |
| Source: | Depression & Anxiety (1091-4269). 2/20/2025, Vol. 2025, p1-12. 12p. |
| Subjects: | Educational attainment, Postpartum depression, Cognitive ability, Mediation (Statistics), Childbearing age, Causal inference, Neuroticism |
| Abstract: | Background: Many studies have explored the relationship between education and postpartum depression (PPD), with inconsistent results. Our study is to identify which education‐related factors (education attainment, qualifications, cognitive performance) played the predominant role in PPD using Mendelian randomization (MR) analysis. Then, we explored the factors that may mediate the effect of education on PPD. Method: We performed two‐sample multivariable Mendelian randomization (MVMR) to assess the independent impact of education‐related factors on PPD. Based on the literature review, three mediating factors that may play a role in the path of education attainment and PPD were involved in mediation analysis, including childbearing age, neuroticism score, and average total household income before tax. Then, we used two‐step MR and MVMR to estimate the indirect effect of these mediators. Results: We identified genetically predicted 1‐SD (3.71 years) higher education attainment (OR: 0.632; [95% confidential interval (CI): 0.464–0.860]); qualifications (OR: 0.418; [95% CI: 0.245–0.714]); or cognitive performance (OR: 0.770; [95% CI: 0.652–0.909]) was associated with lower risk of PPD, and the causal effects of education attainment (OR: 0.407; [95% CI: 0.214–0.773]) on PPD were independent of qualifications and cognition. Childbearing age (β: −0.497; [95% CI: −0.788−0.238]; p < 0.001) and neuroticism score (β: −0.07; [95% CI: −0.120−0.030]; p < 0.001) were identified as mediators of the association between education attainment and PPD. Conclusions: These results suggested the predominant impact of education attainment on PPD independent of qualifications and cognition. Education level mainly affects PPD by changing the childbearing age. Trial Registration: Chinese Clinical Trial Registry identifier: ChiCTR2000033433 [ABSTRACT FROM AUTHOR] |
| Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
|
Full text is not displayed to guests.
Login for full access.
|
|
| Abstract: | Background: Many studies have explored the relationship between education and postpartum depression (PPD), with inconsistent results. Our study is to identify which education‐related factors (education attainment, qualifications, cognitive performance) played the predominant role in PPD using Mendelian randomization (MR) analysis. Then, we explored the factors that may mediate the effect of education on PPD. Method: We performed two‐sample multivariable Mendelian randomization (MVMR) to assess the independent impact of education‐related factors on PPD. Based on the literature review, three mediating factors that may play a role in the path of education attainment and PPD were involved in mediation analysis, including childbearing age, neuroticism score, and average total household income before tax. Then, we used two‐step MR and MVMR to estimate the indirect effect of these mediators. Results: We identified genetically predicted 1‐SD (3.71 years) higher education attainment (OR: 0.632; [95% confidential interval (CI): 0.464–0.860]); qualifications (OR: 0.418; [95% CI: 0.245–0.714]); or cognitive performance (OR: 0.770; [95% CI: 0.652–0.909]) was associated with lower risk of PPD, and the causal effects of education attainment (OR: 0.407; [95% CI: 0.214–0.773]) on PPD were independent of qualifications and cognition. Childbearing age (β: −0.497; [95% CI: −0.788−0.238]; p < 0.001) and neuroticism score (β: −0.07; [95% CI: −0.120−0.030]; p < 0.001) were identified as mediators of the association between education attainment and PPD. Conclusions: These results suggested the predominant impact of education attainment on PPD independent of qualifications and cognition. Education level mainly affects PPD by changing the childbearing age. Trial Registration: Chinese Clinical Trial Registry identifier: ChiCTR2000033433 [ABSTRACT FROM AUTHOR] |
|---|---|
| ISSN: | 10914269 |
| DOI: | 10.1155/da/8835118 |
