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Impact of surgery versus follow-up on psychological distress in patients with indeterminate pulmonary nodules: A prospective observational study.

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Title: Impact of surgery versus follow-up on psychological distress in patients with indeterminate pulmonary nodules: A prospective observational study.
Authors: Wu, Junhan (AUTHOR), Zhuang, Weitao (AUTHOR), Chen, Rixin (AUTHOR), Xu, Haijie (AUTHOR), Li, Zijie (AUTHOR), Lan, Zihua (AUTHOR), Xia, Xin (AUTHOR), He, Zhe (AUTHOR), Li, Shaopeng (AUTHOR), Deng, Cheng (AUTHOR), Xu, Wei (AUTHOR), Shi, Qiuling (AUTHOR), Tang, Yong (AUTHOR), Qiao, Guibin (AUTHOR)
Source: Quality of Life Research. Apr2025, Vol. 34 Issue 4, p1167-1177. 11p.
Subjects: Psychological distress, Surgery, Psychometrics, Scientific observation, Pulmonary nodules, Anxiety, Mental depression, Patient aftercare
Abstract: Purpose: To investigate whether surgery is more effective than follow-up in reducing psychological distress for patients with observable indeterminate pulmonary nodules (IPNs) and to assess if psychological distress can serve as a potential surgical indication for IPNs. Methods: This prospective observational study included 341 patients with abnormal psychometric results, as measured by the Hospital Anxiety and Depression Scale (HADS). Of these, 262 patients opted for follow-up and 79 chose surgery. Initial psychological assessments (HADS1) were conducted at enrollment following nodule detection, with a second assessment (HADS2) one year later. A comparative analysis of dynamic psychological changes (ΔHADS: HADS2—HADS1) between the follow-up and surgical groups was performed. Results: Both groups showed reductions in HADS-A [− 3 (IQR, − 7 to − 1) for follow-up and − 3 (IQR, − 6 to − 1) for surgery] and HADS-D scores [− 2 (IQR, − 4 to 0) for follow-up and − 3 (IQR, − 7 to 0) for surgery]. Univariate analysis revealed that the surgical group had a significantly greater reduction in HADS-D scores compared to the follow-up group (Z = − 2.08, P = 0.037), but there were no significant differences in the changes in HADS-A scores between the groups (Z = − 1.04, P = 0.300). However, in multivariable analysis, surgery did not significantly improve the alleviation of depressive symptoms compared to follow-up (β = − 0.72, 95% CI: − 1.57 to 0.14, P = 0.101). Within the surgical group, female patients reported less relief from anxiety than male patients (Z = − 2.32, P = 0.021), and symptomatic patients experienced less relief from both anxiety (Z = − 2.14, P = 0.032) and depression (Z = − 3.01, P = 0.003). Conclusions: Surgery does not provide additional psychological benefits over follow-up. This study does not support using psychological distress as a criterion for surgical intervention in IPNs from a psychological perspective. Trial registry ClinicalTrials.gov (NCT04857333). [ABSTRACT FROM AUTHOR]
Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: Impact of surgery versus follow-up on psychological distress in patients with indeterminate pulmonary nodules: A prospective observational study.
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  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Wu%2C+Junhan%22">Wu, Junhan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhuang%2C+Weitao%22">Zhuang, Weitao</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Rixin%22">Chen, Rixin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Haijie%22">Xu, Haijie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Zijie%22">Li, Zijie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lan%2C+Zihua%22">Lan, Zihua</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xia%2C+Xin%22">Xia, Xin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22He%2C+Zhe%22">He, Zhe</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Shaopeng%22">Li, Shaopeng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Deng%2C+Cheng%22">Deng, Cheng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Wei%22">Xu, Wei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shi%2C+Qiuling%22">Shi, Qiuling</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tang%2C+Yong%22">Tang, Yong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qiao%2C+Guibin%22">Qiao, Guibin</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Quality+of+Life+Research%22">Quality of Life Research</searchLink>. Apr2025, Vol. 34 Issue 4, p1167-1177. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Psychological+distress%22">Psychological distress</searchLink><br /><searchLink fieldCode="DE" term="%22Surgery%22">Surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Psychometrics%22">Psychometrics</searchLink><br /><searchLink fieldCode="DE" term="%22Scientific+observation%22">Scientific observation</searchLink><br /><searchLink fieldCode="DE" term="%22Pulmonary+nodules%22">Pulmonary nodules</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety%22">Anxiety</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+aftercare%22">Patient aftercare</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: To investigate whether surgery is more effective than follow-up in reducing psychological distress for patients with observable indeterminate pulmonary nodules (IPNs) and to assess if psychological distress can serve as a potential surgical indication for IPNs. Methods: This prospective observational study included 341 patients with abnormal psychometric results, as measured by the Hospital Anxiety and Depression Scale (HADS). Of these, 262 patients opted for follow-up and 79 chose surgery. Initial psychological assessments (HADS1) were conducted at enrollment following nodule detection, with a second assessment (HADS2) one year later. A comparative analysis of dynamic psychological changes (ΔHADS: HADS2—HADS1) between the follow-up and surgical groups was performed. Results: Both groups showed reductions in HADS-A [− 3 (IQR, − 7 to − 1) for follow-up and − 3 (IQR, − 6 to − 1) for surgery] and HADS-D scores [− 2 (IQR, − 4 to 0) for follow-up and − 3 (IQR, − 7 to 0) for surgery]. Univariate analysis revealed that the surgical group had a significantly greater reduction in HADS-D scores compared to the follow-up group (Z = − 2.08, P = 0.037), but there were no significant differences in the changes in HADS-A scores between the groups (Z = − 1.04, P = 0.300). However, in multivariable analysis, surgery did not significantly improve the alleviation of depressive symptoms compared to follow-up (β = − 0.72, 95% CI: − 1.57 to 0.14, P = 0.101). Within the surgical group, female patients reported less relief from anxiety than male patients (Z = − 2.32, P = 0.021), and symptomatic patients experienced less relief from both anxiety (Z = − 2.14, P = 0.032) and depression (Z = − 3.01, P = 0.003). Conclusions: Surgery does not provide additional psychological benefits over follow-up. This study does not support using psychological distress as a criterion for surgical intervention in IPNs from a psychological perspective. Trial registry ClinicalTrials.gov (NCT04857333). [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1007/s11136-024-03876-w
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      – Code: eng
        Text: English
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        PageCount: 11
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    Subjects:
      – SubjectFull: Psychological distress
        Type: general
      – SubjectFull: Surgery
        Type: general
      – SubjectFull: Psychometrics
        Type: general
      – SubjectFull: Scientific observation
        Type: general
      – SubjectFull: Pulmonary nodules
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      – SubjectFull: Anxiety
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      – SubjectFull: Mental depression
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              Text: Apr2025
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