Exploring the interplay between mitochondrial dysfunction, early life adversity and bipolar disorder.
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| Title: | Exploring the interplay between mitochondrial dysfunction, early life adversity and bipolar disorder. |
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| Authors: | Wu, Cheng Ying, Chang, Cheng-Chen, Lin, Ta-Tsung, Liu, Chin-San, Chen, Po See |
| Source: | International Journal of Psychiatry in Clinical Practice. Mar2025, Vol. 29 Issue 1, p25-31. 7p. |
| Subjects: | Bipolar disorder, Risk assessment, Research funding, Questionnaires, Blood collection, Descriptive statistics, Mitochondrial pathology, Comparative studies, Adverse childhood experiences, Mitochondrial DNA, Disease risk factors, Disease complications |
| Abstract: | Objective: Mitochondria are essential for energy production and reactive oxygen species (ROS) generation, with changes in ROS levels or energy demands affecting mitochondrial DNA (mtDNA) copy numbers, indicating mitochondrial function. Early life adversity (ELA) affects mitochondrial dynamics, influencing long-term health. Both ELA and mitochondrial abnormalities have been independently associated with bipolar disorder (BD). This study aims to explore the complex interplay between mitochondrial dysfunction, ELA, and BD. Methods: The study included 60 participants diagnosed with BD and 66 healthy controls (HCs). Data were collected using the Childhood Trauma Questionnaire (CTQ), and leukocyte mtDNA copy number (MCN) was determined from blood samples. Results: The results indicated the CTQ sum scores were significantly higher in the BD group, reflecting greater exposure to ELA. In HCs, a marginally significant nonlinear relationship between the square of the CTQ sum score and MCN was found. Further analysis demonstrated a significant interaction between ELA and BD on MCN (p = 0.023), highlighting a critical connection between ELA and mitochondrial dysfunction in BD and reinforcing its biological underpinnings. Conclusions: Future treatments for BD might target mitochondrial dysfunctions related to chronic stress, with potential pharmaceuticals designed to address these issues and mitigate the negative effects of chronic stress. KEY POINTS: CTQ scores were significantly higher in the BD group. In HCs, there was a marginally significant nonlinear relationship between CTQ and MCN, showing a negative association when CTQ sum score equal or more than 40. Childhood trauma may influence MCN differently in BD patients and HCs, as the effects in BD patients could be obscured by the disorder and medication use. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Objective: Mitochondria are essential for energy production and reactive oxygen species (ROS) generation, with changes in ROS levels or energy demands affecting mitochondrial DNA (mtDNA) copy numbers, indicating mitochondrial function. Early life adversity (ELA) affects mitochondrial dynamics, influencing long-term health. Both ELA and mitochondrial abnormalities have been independently associated with bipolar disorder (BD). This study aims to explore the complex interplay between mitochondrial dysfunction, ELA, and BD. Methods: The study included 60 participants diagnosed with BD and 66 healthy controls (HCs). Data were collected using the Childhood Trauma Questionnaire (CTQ), and leukocyte mtDNA copy number (MCN) was determined from blood samples. Results: The results indicated the CTQ sum scores were significantly higher in the BD group, reflecting greater exposure to ELA. In HCs, a marginally significant nonlinear relationship between the square of the CTQ sum score and MCN was found. Further analysis demonstrated a significant interaction between ELA and BD on MCN (p = 0.023), highlighting a critical connection between ELA and mitochondrial dysfunction in BD and reinforcing its biological underpinnings. Conclusions: Future treatments for BD might target mitochondrial dysfunctions related to chronic stress, with potential pharmaceuticals designed to address these issues and mitigate the negative effects of chronic stress. KEY POINTS: CTQ scores were significantly higher in the BD group. In HCs, there was a marginally significant nonlinear relationship between CTQ and MCN, showing a negative association when CTQ sum score equal or more than 40. Childhood trauma may influence MCN differently in BD patients and HCs, as the effects in BD patients could be obscured by the disorder and medication use. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 13651501 |
| DOI: | 10.1080/13651501.2025.2476505 |
