Histopathologic features of chronic rhinosinusitis with nasal polyps in patients from high-altitude Xizang region.
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| Title: | Histopathologic features of chronic rhinosinusitis with nasal polyps in patients from high-altitude Xizang region. |
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| Authors: | Gao, Yingqi (AUTHOR), Zhang, Qianqian (AUTHOR), Cheng, Fuying (AUTHOR), Zhang, Chen (AUTHOR), Shi, Le (AUTHOR), Chen, Jiani (AUTHOR), Wang, Yizhang (AUTHOR), Cai, Guoyu (AUTHOR), Ge, Sang (AUTHOR), Zhang, Haiyue (AUTHOR), Shi, Fan (AUTHOR), Dan, Zeng (AUTHOR), Ciwang, Zhuoma (AUTHOR), Wang, Huan (AUTHOR), Hu, Li (AUTHOR), Wang, Dehui (AUTHOR), Sun, Xicai (AUTHOR) |
| Source: | Acta Oto-Laryngologica. Jun2025, Vol. 145 Issue 6, p506-511. 6p. |
| Subjects: | Research funding, Sinusitis, Chronic diseases, Nasal polyps, Metaplasia, Inflammation, Health outcome assessment, Comparative studies |
| Geographic Terms: | China |
| Abstract (English): | Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease with varying patterns across regions. Objective: This study aims to investigate the clinical and histopathological features of CRSwNP in Xizang, a high-altitude region in China. Materials and Methods: We retrospectively analyzed the histopathological features of CRSwNP patients from Shanghai and Xizang who underwent functional endoscopic sinus surgery (FESS) between 2017 and 2024. Polyp tissue samples were assessed, and statistical analyses compared features between the two regions in CRSwNP, eosinophilic CRSwNP (eCRSwNP), and noneosinophilic CRSwNP (neCRSwNP) patients. Results: Twenty-eight patients from Xizang and 35 from Shanghai were analyzed. All Shanghai patients were Han Chinese, and all Xizang patients were Tibetan. Compared to Shanghai, Tibetan patients had significantly lower rates of smoking and asthma. Overall inflammation levels in Xizang were lower, while eosinophil counts were lower in eCRSwNP patients. Neutrophil infiltration, mucosal ulceration, and squamous metaplasia were higher in Xizang patients, while neCRSwNP patients exhibited more neutrophil infiltration and less subepithelial edema. Conclusions: The study revealed that Tibetan patients with CRSwNP have lower eosinophilic inflammation but higher neutrophil infiltration and squamous metaplasia compared to Shanghai patients, indicating the impact of high-altitude environments on inflammatory patterns. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): | 对于腮腺肿瘤, 多形性腺瘤 (PA) 和多形性腺瘤癌 (CXPA) 之间的术前甄别诊断仍然具有挑战性。 本研究旨在评估 CXPA 和 PA 的临床特征, 并确定与这些疾病的甄别诊断相关的因素。 我们重审了 2008 年至 2024 年期间在我们机构接受手术治疗的 6 名 CXPA 和 127 名 PA 患者的病历。 单变量分析显示 CXPA 和 PA 患者在自发性疼痛 (p=.044)、面神经麻痹 (p=.045) 和主观扩大 (p <.01) 方面存在显著差异。磁共振成像 (MRI) 显示, CXPA 患者的边界不清、位于深叶和表观扩散系数 (ADC) 较低的肿块比例明显高于 PA 患者 (分别为 p <.01、p=.048 和 p <.01)。多变量分析发现, 自发性疼痛和边界不清的肿块与 CXPA 相关 (分别为 p=.047 和p=.013)。 自发性疼痛和边界不清的肿块可能提示 CXPA 而不是 PA。低 ADC 水平提示可能是 CXPA。 [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease with varying patterns across regions. Objective: This study aims to investigate the clinical and histopathological features of CRSwNP in Xizang, a high-altitude region in China. Materials and Methods: We retrospectively analyzed the histopathological features of CRSwNP patients from Shanghai and Xizang who underwent functional endoscopic sinus surgery (FESS) between 2017 and 2024. Polyp tissue samples were assessed, and statistical analyses compared features between the two regions in CRSwNP, eosinophilic CRSwNP (eCRSwNP), and noneosinophilic CRSwNP (neCRSwNP) patients. Results: Twenty-eight patients from Xizang and 35 from Shanghai were analyzed. All Shanghai patients were Han Chinese, and all Xizang patients were Tibetan. Compared to Shanghai, Tibetan patients had significantly lower rates of smoking and asthma. Overall inflammation levels in Xizang were lower, while eosinophil counts were lower in eCRSwNP patients. Neutrophil infiltration, mucosal ulceration, and squamous metaplasia were higher in Xizang patients, while neCRSwNP patients exhibited more neutrophil infiltration and less subepithelial edema. Conclusions: The study revealed that Tibetan patients with CRSwNP have lower eosinophilic inflammation but higher neutrophil infiltration and squamous metaplasia compared to Shanghai patients, indicating the impact of high-altitude environments on inflammatory patterns. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00016489 |
| DOI: | 10.1080/00016489.2025.2485435 |
