View in EDS HTML Full Text PDF Full Text

Exploring the relationship between dystonia and STN-DBS in Parkinson's disease: insights from a single-centre cohort.

Saved in:
Bibliographic Details
Title: Exploring the relationship between dystonia and STN-DBS in Parkinson's disease: insights from a single-centre cohort.
Authors: Remore, Luigi G. (AUTHOR), Gagliardi, Delia (AUTHOR), Borellini, Linda (AUTHOR), Fasano, Alfonso (AUTHOR), Faso, Valeria Lo (AUTHOR), Cogiamanian, Filippo (AUTHOR), Mailand, Enrico (AUTHOR), Valcamonica, Gloria (AUTHOR), Pirola, Elena (AUTHOR), Schisano, Luigi (AUTHOR), Ampollini, Antonella M. (AUTHOR), Bertani, Giulio A. (AUTHOR), Fiore, Giorgio (AUTHOR), D'Ammando, Antonio (AUTHOR), Tariciotti, Leonardo (AUTHOR), Marfia, Giovanni (AUTHOR), Navone, Stefania Elena (AUTHOR), Barbieri, Sergio (AUTHOR), Locatelli, Marco (AUTHOR)
Source: Neurological Sciences. Aug2025, Vol. 46 Issue 8, p3691-3701. 11p.
Subjects: Deep brain stimulation, Parkinson's disease, Subthalamic nucleus, Statistical significance, Neural pathways
Abstract: Introduction: Motor side effects may emerge after deep brain stimulation (DBS) of the subthalamic nucleus (STN) in Parkinson's disease (PD) patients. Out of 60 PD patients, we observed 16 patients displaying de novo dystonic symptoms after the implantation and 11 dystonic PD patients without benefit from the stimulation. We hypothesized that a common neural pathway may cause dystonia in both conditions. Our study aims to investigate the clinical and connectivity substrates of dystonia after STN-DBS. Methods: We divided our cohort into four groups: 16 patients displaying dystonia after STN-DBS, 11 patients with previously known dystonia not improving after surgery, 14 patients with dystonic symptoms relieved by the stimulation and 19 controls who never experienced dystonia. MANOVA was used to compare clinical data and the distance of the active contact center from the STN border among the four groups. Finally, we reconstructed the "sour" spots for dystonic symptoms and the associated structural and functional connectivity using a Parkinsonian normative connectome. Results: De novo dystonic and not-improved dystonic patients had a statistically significant longer PD duration before surgery (p = 0.001) and a greater active contact-STN distance (p < 0.001). Moreover, the "sour" spots were similar in both groups and structural and functional connectivity profiles were associated with brain areas correlated with dystonia pathophysiology (cerebellum, midbrain, parietal and temporal cortices). Conclusions: We formulated a two-hit model for dystonia after STN-DBS: a clinical feature of Parkinsonian patients causes predisposing altered plasticity contributing to dystonic symptoms development when coupled with the stimulation of dystonia-related subcortical and cortical structures. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 186678278
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Exploring the relationship between dystonia and STN-DBS in Parkinson&#39;s disease: insights from a single-centre cohort.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Remore%2C+Luigi+G%2E%22&quot;&gt;Remore, Luigi G.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gagliardi%2C+Delia%22&quot;&gt;Gagliardi, Delia&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Borellini%2C+Linda%22&quot;&gt;Borellini, Linda&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Fasano%2C+Alfonso%22&quot;&gt;Fasano, Alfonso&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Faso%2C+Valeria+Lo%22&quot;&gt;Faso, Valeria Lo&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cogiamanian%2C+Filippo%22&quot;&gt;Cogiamanian, Filippo&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mailand%2C+Enrico%22&quot;&gt;Mailand, Enrico&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Valcamonica%2C+Gloria%22&quot;&gt;Valcamonica, Gloria&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pirola%2C+Elena%22&quot;&gt;Pirola, Elena&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Schisano%2C+Luigi%22&quot;&gt;Schisano, Luigi&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ampollini%2C+Antonella+M%2E%22&quot;&gt;Ampollini, Antonella M.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bertani%2C+Giulio+A%2E%22&quot;&gt;Bertani, Giulio A.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Fiore%2C+Giorgio%22&quot;&gt;Fiore, Giorgio&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22D&#39;Ammando%2C+Antonio%22&quot;&gt;D&#39;Ammando, Antonio&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tariciotti%2C+Leonardo%22&quot;&gt;Tariciotti, Leonardo&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Marfia%2C+Giovanni%22&quot;&gt;Marfia, Giovanni&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Navone%2C+Stefania+Elena%22&quot;&gt;Navone, Stefania Elena&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Barbieri%2C+Sergio%22&quot;&gt;Barbieri, Sergio&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Locatelli%2C+Marco%22&quot;&gt;Locatelli, Marco&lt;/searchLink&gt; (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Neurological+Sciences%22&quot;&gt;Neurological Sciences&lt;/searchLink&gt;. Aug2025, Vol. 46 Issue 8, p3691-3701. 11p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Deep+brain+stimulation%22&quot;&gt;Deep brain stimulation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Parkinson&#39;s+disease%22&quot;&gt;Parkinson&#39;s disease&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Subthalamic+nucleus%22&quot;&gt;Subthalamic nucleus&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Statistical+significance%22&quot;&gt;Statistical significance&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Neural+pathways%22&quot;&gt;Neural pathways&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Introduction: Motor side effects may emerge after deep brain stimulation (DBS) of the subthalamic nucleus (STN) in Parkinson&#39;s disease (PD) patients. Out of 60 PD patients, we observed 16 patients displaying de novo dystonic symptoms after the implantation and 11 dystonic PD patients without benefit from the stimulation. We hypothesized that a common neural pathway may cause dystonia in both conditions. Our study aims to investigate the clinical and connectivity substrates of dystonia after STN-DBS. Methods: We divided our cohort into four groups: 16 patients displaying dystonia after STN-DBS, 11 patients with previously known dystonia not improving after surgery, 14 patients with dystonic symptoms relieved by the stimulation and 19 controls who never experienced dystonia. MANOVA was used to compare clinical data and the distance of the active contact center from the STN border among the four groups. Finally, we reconstructed the &quot;sour&quot; spots for dystonic symptoms and the associated structural and functional connectivity using a Parkinsonian normative connectome. Results: De novo dystonic and not-improved dystonic patients had a statistically significant longer PD duration before surgery (p = 0.001) and a greater active contact-STN distance (p &lt; 0.001). Moreover, the &quot;sour&quot; spots were similar in both groups and structural and functional connectivity profiles were associated with brain areas correlated with dystonia pathophysiology (cerebellum, midbrain, parietal and temporal cortices). Conclusions: We formulated a two-hit model for dystonia after STN-DBS: a clinical feature of Parkinsonian patients causes predisposing altered plasticity contributing to dystonic symptoms development when coupled with the stimulation of dystonia-related subcortical and cortical structures. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=186678278
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s10072-025-08230-7
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 11
        StartPage: 3691
    Subjects:
      – SubjectFull: Deep brain stimulation
        Type: general
      – SubjectFull: Parkinson's disease
        Type: general
      – SubjectFull: Subthalamic nucleus
        Type: general
      – SubjectFull: Statistical significance
        Type: general
      – SubjectFull: Neural pathways
        Type: general
    Titles:
      – TitleFull: Exploring the relationship between dystonia and STN-DBS in Parkinson's disease: insights from a single-centre cohort.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Remore, Luigi G.
      – PersonEntity:
          Name:
            NameFull: Gagliardi, Delia
      – PersonEntity:
          Name:
            NameFull: Borellini, Linda
      – PersonEntity:
          Name:
            NameFull: Fasano, Alfonso
      – PersonEntity:
          Name:
            NameFull: Faso, Valeria Lo
      – PersonEntity:
          Name:
            NameFull: Cogiamanian, Filippo
      – PersonEntity:
          Name:
            NameFull: Mailand, Enrico
      – PersonEntity:
          Name:
            NameFull: Valcamonica, Gloria
      – PersonEntity:
          Name:
            NameFull: Pirola, Elena
      – PersonEntity:
          Name:
            NameFull: Schisano, Luigi
      – PersonEntity:
          Name:
            NameFull: Ampollini, Antonella M.
      – PersonEntity:
          Name:
            NameFull: Bertani, Giulio A.
      – PersonEntity:
          Name:
            NameFull: Fiore, Giorgio
      – PersonEntity:
          Name:
            NameFull: D'Ammando, Antonio
      – PersonEntity:
          Name:
            NameFull: Tariciotti, Leonardo
      – PersonEntity:
          Name:
            NameFull: Marfia, Giovanni
      – PersonEntity:
          Name:
            NameFull: Navone, Stefania Elena
      – PersonEntity:
          Name:
            NameFull: Barbieri, Sergio
      – PersonEntity:
          Name:
            NameFull: Locatelli, Marco
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: Aug2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 15901874
          Numbering:
            – Type: volume
              Value: 46
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: Neurological Sciences
              Type: main
ResultId 1