A Descriptive Assessment of Products Containing the Opioid Receptor Stimulator Mitragynine Pseudoindoxyl.
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| Title: | A Descriptive Assessment of Products Containing the Opioid Receptor Stimulator Mitragynine Pseudoindoxyl. |
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| Authors: | White, C. Michael (AUTHOR), Belcourt, Jordyn (AUTHOR), Sedensky, Ava (AUTHOR) |
| Source: | Substance Use & Misuse. 2025, Vol. 60 Issue 12, p1950-1954. 5p. |
| Subjects: | Odors, Labels, World Wide Web, Alkaloids, Flavoring essences, Sales personnel, Plant extracts, Commercial product evaluation, Elemental diet, Medicinal plants, Opioid receptors, Dietary supplements |
| Abstract: | Background: Potent semi-synthetic alkaloids that stimulate opioid receptors are being sold to consumers in gas stations, smoke shops, and online as the dietary supplement 'kratom'. Objective: We descriptively evaluated the characteristics of products containing mitragynine pseudoindoxyl. Results: Fifty-one unique products met our inclusion criteria. Seventy-one percent of products contained mitragynine pseudoindoxyl plus 7-hydroxymitragynine, 24% contained mitragynine pseudoindoxyl alone (24%), and 6% contained mitragynine pseudoindoxyl with 8-hydroxymitragynine or 11-hydroxymitragynine (with or without 7-hydroxymitragynine). Sixty-nine percent of products had a child appealing flavoring and/or scent, 63% of products were formulated using bright colors or had bright colors on their labeling, 12% of products had food pictures on the label (mainly representing the fruit or mint flavoring/scent), 6% of products had a cartoon mascot, and 6% of products had a food formulation (ice cream cone or chocolate bar). Only 18% of websites disclosed the products stimulated opioid receptors while 45% disclosed they could cause intoxication, tolerance, dependence, withdrawal, or addiction. Conclusions: There are many products that contain mitragynine pseudoindoxyl sold as dietary supplements and many have features that would appeal to children. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Background: Potent semi-synthetic alkaloids that stimulate opioid receptors are being sold to consumers in gas stations, smoke shops, and online as the dietary supplement 'kratom'. Objective: We descriptively evaluated the characteristics of products containing mitragynine pseudoindoxyl. Results: Fifty-one unique products met our inclusion criteria. Seventy-one percent of products contained mitragynine pseudoindoxyl plus 7-hydroxymitragynine, 24% contained mitragynine pseudoindoxyl alone (24%), and 6% contained mitragynine pseudoindoxyl with 8-hydroxymitragynine or 11-hydroxymitragynine (with or without 7-hydroxymitragynine). Sixty-nine percent of products had a child appealing flavoring and/or scent, 63% of products were formulated using bright colors or had bright colors on their labeling, 12% of products had food pictures on the label (mainly representing the fruit or mint flavoring/scent), 6% of products had a cartoon mascot, and 6% of products had a food formulation (ice cream cone or chocolate bar). Only 18% of websites disclosed the products stimulated opioid receptors while 45% disclosed they could cause intoxication, tolerance, dependence, withdrawal, or addiction. Conclusions: There are many products that contain mitragynine pseudoindoxyl sold as dietary supplements and many have features that would appeal to children. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 10826084 |
| DOI: | 10.1080/10826084.2025.2522162 |