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SALICYLIC ACID SENSOR1 reveals the propagation of an SA hormone surge during plant pathogen advance.

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Title: SALICYLIC ACID SENSOR1 reveals the propagation of an SA hormone surge during plant pathogen advance.
Authors: Tang, Bijun, Lu, Jing, Leontovyčová, Hana, Hoffmann, Gesa, Rowe, James H., O'Donnell, Sacha Fouquay, Grangé-Guermente, Mathieu, Larsen, Bo, Wimalasekera, Rinukshi, Carella, Philip, Incarbone, Marco, Kalachova, Tetiana, Jones, Alexander M.
Source: Science. 10/9/2025, Vol. 390 Issue 6769, p188-194. 7p.
Subjects: Salicylic acid, Plant hormones, Phytopathogenic microorganisms, Fluorescence resonance energy transfer, Biosensors, Bacterial diseases
Abstract: Salicylic acid (SA) is a key phytohormone that orchestrates immune responses against pathogens, including Pseudomonas syringae bacteria. The timing and extent of SA accumulation are tightly controlled by plants but can be suppressed by pathogens to overcome immunity. Understanding SA dynamics at high spatiotemporal resolution remains challenging owing to limitations in existing detection methods that are indirect, destructive, or lacking in cellular precision and temporal resolution. We developed SalicS1, a genetically encoded fluorescence resonance energy transfer (FRET) biosensor specific to SA. SalicS1 enables real-time, reversible monitoring of SA levels in vivo with minimal perturbation of endogenous signaling. We reveal the propagation of an SA surge spreading from bacterial infection sites with spatiotemporal fidelity. SalicS1 unlocks precise understanding of SA dynamics underpinning crop resilience to pathogens. Editor's summary: Visualizing and quantifying the amount of a hormone within a cell can be achieved using fluorescence resonance energy transfer (FRET) sensors. These sensors involve a hormone binding to a pair of linked proteins, which then undergo conformational changes to alter the fluorescence emission ratio of two connected fluorescent proteins. Tang et al. have developed a FRET sensor for the plant hormone salicylic acid, which is primarily involved in activating immune responses. Using this sensor, the authors were able to visualize hormone levels with high sensitivity and spatial resolution at the cellular level and observed varied dynamics and patterns of salicylic acid up-regulation in response to bacterial infections. —Madeleine Seale [ABSTRACT FROM AUTHOR]
Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: SALICYLIC ACID SENSOR1 reveals the propagation of an SA hormone surge during plant pathogen advance.
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  Data: <searchLink fieldCode="AR" term="%22Tang%2C+Bijun%22">Tang, Bijun</searchLink><br /><searchLink fieldCode="AR" term="%22Lu%2C+Jing%22">Lu, Jing</searchLink><br /><searchLink fieldCode="AR" term="%22Leontovyčová%2C+Hana%22">Leontovyčová, Hana</searchLink><br /><searchLink fieldCode="AR" term="%22Hoffmann%2C+Gesa%22">Hoffmann, Gesa</searchLink><br /><searchLink fieldCode="AR" term="%22Rowe%2C+James+H%2E%22">Rowe, James H.</searchLink><br /><searchLink fieldCode="AR" term="%22O'Donnell%2C+Sacha+Fouquay%22">O'Donnell, Sacha Fouquay</searchLink><br /><searchLink fieldCode="AR" term="%22Grangé-Guermente%2C+Mathieu%22">Grangé-Guermente, Mathieu</searchLink><br /><searchLink fieldCode="AR" term="%22Larsen%2C+Bo%22">Larsen, Bo</searchLink><br /><searchLink fieldCode="AR" term="%22Wimalasekera%2C+Rinukshi%22">Wimalasekera, Rinukshi</searchLink><br /><searchLink fieldCode="AR" term="%22Carella%2C+Philip%22">Carella, Philip</searchLink><br /><searchLink fieldCode="AR" term="%22Incarbone%2C+Marco%22">Incarbone, Marco</searchLink><br /><searchLink fieldCode="AR" term="%22Kalachova%2C+Tetiana%22">Kalachova, Tetiana</searchLink><br /><searchLink fieldCode="AR" term="%22Jones%2C+Alexander+M%2E%22">Jones, Alexander M.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science%22">Science</searchLink>. 10/9/2025, Vol. 390 Issue 6769, p188-194. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Salicylic+acid%22">Salicylic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Plant+hormones%22">Plant hormones</searchLink><br /><searchLink fieldCode="DE" term="%22Phytopathogenic+microorganisms%22">Phytopathogenic microorganisms</searchLink><br /><searchLink fieldCode="DE" term="%22Fluorescence+resonance+energy+transfer%22">Fluorescence resonance energy transfer</searchLink><br /><searchLink fieldCode="DE" term="%22Biosensors%22">Biosensors</searchLink><br /><searchLink fieldCode="DE" term="%22Bacterial+diseases%22">Bacterial diseases</searchLink>
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  Data: Salicylic acid (SA) is a key phytohormone that orchestrates immune responses against pathogens, including Pseudomonas syringae bacteria. The timing and extent of SA accumulation are tightly controlled by plants but can be suppressed by pathogens to overcome immunity. Understanding SA dynamics at high spatiotemporal resolution remains challenging owing to limitations in existing detection methods that are indirect, destructive, or lacking in cellular precision and temporal resolution. We developed SalicS1, a genetically encoded fluorescence resonance energy transfer (FRET) biosensor specific to SA. SalicS1 enables real-time, reversible monitoring of SA levels in vivo with minimal perturbation of endogenous signaling. We reveal the propagation of an SA surge spreading from bacterial infection sites with spatiotemporal fidelity. SalicS1 unlocks precise understanding of SA dynamics underpinning crop resilience to pathogens. Editor's summary: Visualizing and quantifying the amount of a hormone within a cell can be achieved using fluorescence resonance energy transfer (FRET) sensors. These sensors involve a hormone binding to a pair of linked proteins, which then undergo conformational changes to alter the fluorescence emission ratio of two connected fluorescent proteins. Tang et al. have developed a FRET sensor for the plant hormone salicylic acid, which is primarily involved in activating immune responses. Using this sensor, the authors were able to visualize hormone levels with high sensitivity and spatial resolution at the cellular level and observed varied dynamics and patterns of salicylic acid up-regulation in response to bacterial infections. —Madeleine Seale [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Text: English
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      – SubjectFull: Phytopathogenic microorganisms
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              Text: 10/9/2025
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