Risk of Neurodevelopmental Disorders in Offspring of Parents with Major Depressive Disorder: A Birth Cohort Study.
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| Title: | Risk of Neurodevelopmental Disorders in Offspring of Parents with Major Depressive Disorder: A Birth Cohort Study. |
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| Authors: | Lin, Yu-Han (AUTHOR), Tsai, Shih-Jen (AUTHOR), Bai, Ya-Mei (AUTHOR), Chen, Tzeng-Ji (AUTHOR), Chen, Mu-Hong (AUTHOR) |
| Source: | Journal of Autism & Developmental Disorders. Nov2025, Vol. 55 Issue 11, p4009-4017. 9p. |
| Subjects: | Autism risk factors, Risk factors of attention-deficit hyperactivity disorder, Risk assessment, Pearson correlation (Statistics), Child psychopathology, Tic disorders, Research funding, Children of parents with disabilities, Mothers, Sex distribution, Socioeconomic factors, Parent-child relationships, Retrospective studies, Descriptive statistics, Chi-squared test, Age distribution, Longitudinal method, Odds ratio, Developmental disabilities, Fathers, Medical records, Acquisition of data, Psychology of parents, Comparative studies, Data analysis software, Confidence intervals, Asperger's syndrome, Psychosocial factors, Mental depression, Regression analysis, Disease risk factors |
| Geographic Terms: | Taiwan |
| Abstract: | Studies have reported inconsistent results regarding associations between parental depression and offspring neurodevelopmental disorders, such as developmental delay and autism spectrum disorder (ASD). In all, 7,593 children who were born between 1996 and 2010 in Taiwan and had at least one parent with major depressive disorder and 75,930 birth-year- and sex-matched children of parents without major depressive disorder were followed from 1996 or time of birth to the end of 2011. Intergroup differences in neurodevelopmental conditions—including ASD, attention-deficit hyperactivity disorder (ADHD), tic disorder, developmental delay, and intellectual disability (ID)—were assessed. Compared with the children in the control group, the children of parents with major depression were more likely [hazard ratio (HR), 95% confidence interval (CI)] to develop ADHD (1.98, 1.80–2.18), ASD (1.52, 1.16–1.94), tic disorder (1.40, 1.08–1.81), developmental delay (1.32, 1.20–1.45), and ID (1.26, 1.02–1.55). Parental depression was associated with offspring neurodevelopmental disorders, specifically ASD, ADHD, developmental delay, ID, and tic disorder. Therefore, clinicians should closely monitor the neurodevelopmental conditions of children of parents with depression. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Studies have reported inconsistent results regarding associations between parental depression and offspring neurodevelopmental disorders, such as developmental delay and autism spectrum disorder (ASD). In all, 7,593 children who were born between 1996 and 2010 in Taiwan and had at least one parent with major depressive disorder and 75,930 birth-year- and sex-matched children of parents without major depressive disorder were followed from 1996 or time of birth to the end of 2011. Intergroup differences in neurodevelopmental conditions—including ASD, attention-deficit hyperactivity disorder (ADHD), tic disorder, developmental delay, and intellectual disability (ID)—were assessed. Compared with the children in the control group, the children of parents with major depression were more likely [hazard ratio (HR), 95% confidence interval (CI)] to develop ADHD (1.98, 1.80–2.18), ASD (1.52, 1.16–1.94), tic disorder (1.40, 1.08–1.81), developmental delay (1.32, 1.20–1.45), and ID (1.26, 1.02–1.55). Parental depression was associated with offspring neurodevelopmental disorders, specifically ASD, ADHD, developmental delay, ID, and tic disorder. Therefore, clinicians should closely monitor the neurodevelopmental conditions of children of parents with depression. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 01623257 |
| DOI: | 10.1007/s10803-024-06502-3 |
