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Home-based transcranial direct current stimulation (tDCS) for bipolar depression: effects on quality of life and functioning—an open-label study.

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Title: Home-based transcranial direct current stimulation (tDCS) for bipolar depression: effects on quality of life and functioning—an open-label study.
Authors: Rezaei, Hakimeh (AUTHOR), Woodham, Rachel D. (AUTHOR), Ghazi-Noori, Ali-Reza (AUTHOR), Bramon, Elvira (AUTHOR), Bauer, Michael (AUTHOR), Young, Allan H. (AUTHOR), Fu, Cynthia H. Y. (AUTHOR), Ritter, Philipp (AUTHOR)
Source: Quality of Life Research. Feb2026, Vol. 35 Issue 2, p1-13. 13p.
Subjects: Bipolar disorder, Transcranial direct current stimulation, Neural stimulation, Scientific observation, Supervision, Quality of life, Mental depression
Abstract: Purpose: Individuals with bipolar disorder often experience reduced quality of life (QoL). Transcranial direct current stimulation (tDCS) is a promising non-invasive treatment for bipolar depression that is portable, safe, and suitable for use at home. We developed a home-based tDCS protocol with real-time remote supervision and examined its effect on QoL in bipolar depression. Methods: In an open‐label design, 44 participants (31 women) with bipolar depression of at least a moderate severity received 21 sessions of home‐based tDCS (2 mA, 30 min, F3 anode/F4 cathode) over 6 weeks, with a follow-up visit conducted 5 months from baseline. QoL was assessed using the quality of life enjoyment and satisfaction questionnaire (Q-LES-Q) at baseline, week 2, end of treatment, and follow-up session. Baseline and post treatment scores were compared with healthy control participants (28 adults; 17 women). Results: At baseline and at the end of treatment, bipolar participants showed a significantly lower Q-LES-Q score than healthy controls (p < 0.001). Within the bipolar group, there was a significant improvement in total Q-LES-Q scores (p < 0.001) and across multiple domains by week 6 and remained elevated at follow-up. Changes in Q-LES-Q were no longer significant after adjustment for depressive symptoms. Conclusion: A 6-week course of supervised home-based tDCS was associated with significant QoL improvements in bipolar depression, which appeared to be closely linked to reduction in depressive symptoms. Randomized, sham‐controlled trials are warranted to clarify the specific contribution of tDCS to improve QoL in bipolar depression. [ABSTRACT FROM AUTHOR]
Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Home-based transcranial direct current stimulation (tDCS) for bipolar depression: effects on quality of life and functioning—an open-label study.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rezaei%2C+Hakimeh%22&quot;&gt;Rezaei, Hakimeh&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Woodham%2C+Rachel+D%2E%22&quot;&gt;Woodham, Rachel D.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ghazi-Noori%2C+Ali-Reza%22&quot;&gt;Ghazi-Noori, Ali-Reza&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bramon%2C+Elvira%22&quot;&gt;Bramon, Elvira&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bauer%2C+Michael%22&quot;&gt;Bauer, Michael&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Young%2C+Allan+H%2E%22&quot;&gt;Young, Allan H.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Fu%2C+Cynthia+H%2E+Y%2E%22&quot;&gt;Fu, Cynthia H. Y.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ritter%2C+Philipp%22&quot;&gt;Ritter, Philipp&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Quality+of+Life+Research%22&quot;&gt;Quality of Life Research&lt;/searchLink&gt;. Feb2026, Vol. 35 Issue 2, p1-13. 13p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Bipolar+disorder%22&quot;&gt;Bipolar disorder&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Transcranial+direct+current+stimulation%22&quot;&gt;Transcranial direct current stimulation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Neural+stimulation%22&quot;&gt;Neural stimulation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Scientific+observation%22&quot;&gt;Scientific observation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Supervision%22&quot;&gt;Supervision&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Quality+of+life%22&quot;&gt;Quality of life&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mental+depression%22&quot;&gt;Mental depression&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: Individuals with bipolar disorder often experience reduced quality of life (QoL). Transcranial direct current stimulation (tDCS) is a promising non-invasive treatment for bipolar depression that is portable, safe, and suitable for use at home. We developed a home-based tDCS protocol with real-time remote supervision and examined its effect on QoL in bipolar depression. Methods: In an open‐label design, 44 participants (31 women) with bipolar depression of at least a moderate severity received 21 sessions of home‐based tDCS (2 mA, 30 min, F3 anode/F4 cathode) over 6 weeks, with a follow-up visit conducted 5 months from baseline. QoL was assessed using the quality of life enjoyment and satisfaction questionnaire (Q-LES-Q) at baseline, week 2, end of treatment, and follow-up session. Baseline and post treatment scores were compared with healthy control participants (28 adults; 17 women). Results: At baseline and at the end of treatment, bipolar participants showed a significantly lower Q-LES-Q score than healthy controls (p &lt; 0.001). Within the bipolar group, there was a significant improvement in total Q-LES-Q scores (p &lt; 0.001) and across multiple domains by week 6 and remained elevated at follow-up. Changes in Q-LES-Q were no longer significant after adjustment for depressive symptoms. Conclusion: A 6-week course of supervised home-based tDCS was associated with significant QoL improvements in bipolar depression, which appeared to be closely linked to reduction in depressive symptoms. Randomized, sham‐controlled trials are warranted to clarify the specific contribution of tDCS to improve QoL in bipolar depression. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=190820456
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      – Type: doi
        Value: 10.1007/s11136-025-04135-2
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        Text: English
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        PageCount: 13
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    Subjects:
      – SubjectFull: Bipolar disorder
        Type: general
      – SubjectFull: Transcranial direct current stimulation
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      – SubjectFull: Neural stimulation
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      – SubjectFull: Supervision
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      – SubjectFull: Quality of life
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      – SubjectFull: Mental depression
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      – TitleFull: Home-based transcranial direct current stimulation (tDCS) for bipolar depression: effects on quality of life and functioning—an open-label study.
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              Text: Feb2026
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              Y: 2026
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