Bibliographic Details
| Title: |
Risk factors and outcome of dopamine dysregulation syndrome in a large Chinese Parkinson’s disease cohort. |
| Authors: |
Xiao, Yi (AUTHOR), Kang, Simin (AUTHOR), Ou, Ruwei (AUTHOR), Lin, Junyu (AUTHOR), Yang, Tianmi (AUTHOR), Jiang, Qirui (AUTHOR), Song, Wei (AUTHOR), Shang, Huifang (AUTHOR) |
| Source: |
Neurological Sciences. Jan2026, Vol. 47 Issue 1, p1-8. 8p. |
| Abstract: |
Background: There is a lack of large sample-size studies on the prevalence and outcome of Dopamine dysregulation syndrome (DDS) in Chinese Parkinson’s disease (PD) patients. Method: A total of 706 patients with PD were included in the study. Patients were divided into DDS and non-DDS groups according to whether they met the diagnostic criteria for DDS. The outcome of DDS in patients with DDS was followed up by telephone. Result: DDS was diagnosed in 29 of 706 (4.1%) patients. Compared to non-DDS patients, DDS patients had an early age of onset, longer disease duration, a high percentage of impulse control disorder, dyskinesia, and motor fluctuation, higher Hoehn-Yahr stage, and higher scores of non-motor symptoms. Higher levodopa equivalent daily dose (LEDD) (OR [95% CI] = 1.47 [1.10, 2.00], P = 0.010) and severe depressive symptoms (OR [95% CI] = 3.15 [1.39, 7.33], P = 0.007) were risk factors for DDS in PD patients. After a mean follow-up of 2.94 ± 0.94 years, 24 patients with DDS were reached, and only three patients had persistent DDS. Youden index and univariate logistic regression model found that baseline LEDD ≧ 950 mg/day was an effective predictor for persistent DDS. Conclusion: The high disease burden of DDS emphasized the need for the prevention of DDS in the clinic. Controlling LEDD was important for preventing persistent DDS, and we provided a recommendation LEDD cutoff to prevent persistent DDS in Chinese PD patients. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
