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Mid‐childhood developmental and behavioural outcomes in infants with a family history of autism and/or attention deficit hyperactivity disorder.

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Title: Mid‐childhood developmental and behavioural outcomes in infants with a family history of autism and/or attention deficit hyperactivity disorder.
Authors: Charman, Tony (AUTHOR), Bazelmans, Tessel (AUTHOR), Pasco, Greg (AUTHOR), Begum Ali, Jannath (AUTHOR), Johnson, Mark H. (AUTHOR), Jones, Emily J. H. (AUTHOR)
Source: Journal of Child Psychology & Psychiatry. Feb2026, Vol. 67 Issue 2, p282-295. 14p.
Subjects: Autism risk factors, Risk factors of attention-deficit hyperactivity disorder, Risk assessment, Infant development, Infant psychology, Research funding, Data analysis, Income, Multiple regression analysis, Sex distribution, Questionnaires, Family history (Medicine), Descriptive statistics, Chi-squared test, Multivariate analysis, Longitudinal method, Analysis of variance, Statistics, Asperger's syndrome, Children
Abstract: Background: Prospective studies of autism family history infants primarily report recurrence and predictors of autism at 3 years. Less is known about ADHD family history infants and later childhood outcomes. We characterise profiles of mid‐childhood developmental and behavioural outcomes in infants with a family history of autism and/or ADHD to identify potential support needs and patterns of co‐occurrence across domains. Methods: Two hundred and sixty‐three infants (51% male; N = 198 autism/ADHD family history; N = 65 no family history) were assessed at 6–12 years. A latent profile analysis (LPA) with indicator variables measuring developmental abilities (IQ, adaptive function) and behavioural traits (autism, ADHD, anxiety) identified dimensional, data‐derived outcome classes. Results: A seven‐class solution was the most robust and clinically meaningful. Two classes (27% and 23%) had typical development; two classes had high autism, ADHD, and anxiety traits—one with low IQ and adaptive function (10%) and one with average IQ but low adaptive function (13%); one class had elevated autism and ADHD but not anxiety traits (10%); and the final two classes had elevated ADHD (9%) and anxiety (8%) traits in isolation. Sex distribution was balanced across all classes. Children with autism were found in all classes but predominantly in the classes with low IQ/adaptive functioning and high behavioural traits, as well as in the class with elevated autism and ADHD traits. We found only partial continuity between membership of similarly derived 3‐year LPA classes and mid‐childhood LPA classes. Conclusions: Many autism/ADHD family history infants develop typically. However, by mid‐childhood, in addition to those with autism, others show elevated neurodevelopmental (autism, ADHD) and neuropsychiatric (anxiety) behavioural traits. Lower developmental abilities (IQ and adaptive function) are primarily seen in children with an autism diagnosis. Family history infants should be monitored through childhood, and support provided should challenges emerge. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Mid‐childhood developmental and behavioural outcomes in infants with a family history of autism and/or attention deficit hyperactivity disorder.
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  Data: <searchLink fieldCode="AR" term="%22Charman%2C+Tony%22">Charman, Tony</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bazelmans%2C+Tessel%22">Bazelmans, Tessel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pasco%2C+Greg%22">Pasco, Greg</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Begum+Ali%2C+Jannath%22">Begum Ali, Jannath</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Johnson%2C+Mark+H%2E%22">Johnson, Mark H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jones%2C+Emily+J%2E+H%2E%22">Jones, Emily J. H.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Child+Psychology+%26+Psychiatry%22">Journal of Child Psychology & Psychiatry</searchLink>. Feb2026, Vol. 67 Issue 2, p282-295. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Autism+risk+factors%22">Autism risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+factors+of+attention-deficit+hyperactivity+disorder%22">Risk factors of attention-deficit hyperactivity disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Infant+development%22">Infant development</searchLink><br /><searchLink fieldCode="DE" term="%22Infant+psychology%22">Infant psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis%22">Data analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Income%22">Income</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+regression+analysis%22">Multiple regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Sex+distribution%22">Sex distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Family+history+%28Medicine%29%22">Family history (Medicine)</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Chi-squared+test%22">Chi-squared test</searchLink><br /><searchLink fieldCode="DE" term="%22Multivariate+analysis%22">Multivariate analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Analysis+of+variance%22">Analysis of variance</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Asperger's+syndrome%22">Asperger's syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Children%22">Children</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Prospective studies of autism family history infants primarily report recurrence and predictors of autism at 3 years. Less is known about ADHD family history infants and later childhood outcomes. We characterise profiles of mid‐childhood developmental and behavioural outcomes in infants with a family history of autism and/or ADHD to identify potential support needs and patterns of co‐occurrence across domains. Methods: Two hundred and sixty‐three infants (51% male; N = 198 autism/ADHD family history; N = 65 no family history) were assessed at 6–12 years. A latent profile analysis (LPA) with indicator variables measuring developmental abilities (IQ, adaptive function) and behavioural traits (autism, ADHD, anxiety) identified dimensional, data‐derived outcome classes. Results: A seven‐class solution was the most robust and clinically meaningful. Two classes (27% and 23%) had typical development; two classes had high autism, ADHD, and anxiety traits—one with low IQ and adaptive function (10%) and one with average IQ but low adaptive function (13%); one class had elevated autism and ADHD but not anxiety traits (10%); and the final two classes had elevated ADHD (9%) and anxiety (8%) traits in isolation. Sex distribution was balanced across all classes. Children with autism were found in all classes but predominantly in the classes with low IQ/adaptive functioning and high behavioural traits, as well as in the class with elevated autism and ADHD traits. We found only partial continuity between membership of similarly derived 3‐year LPA classes and mid‐childhood LPA classes. Conclusions: Many autism/ADHD family history infants develop typically. However, by mid‐childhood, in addition to those with autism, others show elevated neurodevelopmental (autism, ADHD) and neuropsychiatric (anxiety) behavioural traits. Lower developmental abilities (IQ and adaptive function) are primarily seen in children with an autism diagnosis. Family history infants should be monitored through childhood, and support provided should challenges emerge. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=190935723
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/jcpp.70048
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 14
        StartPage: 282
    Subjects:
      – SubjectFull: Autism risk factors
        Type: general
      – SubjectFull: Risk factors of attention-deficit hyperactivity disorder
        Type: general
      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Infant development
        Type: general
      – SubjectFull: Infant psychology
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Data analysis
        Type: general
      – SubjectFull: Income
        Type: general
      – SubjectFull: Multiple regression analysis
        Type: general
      – SubjectFull: Sex distribution
        Type: general
      – SubjectFull: Questionnaires
        Type: general
      – SubjectFull: Family history (Medicine)
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Chi-squared test
        Type: general
      – SubjectFull: Multivariate analysis
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Analysis of variance
        Type: general
      – SubjectFull: Statistics
        Type: general
      – SubjectFull: Asperger's syndrome
        Type: general
      – SubjectFull: Children
        Type: general
    Titles:
      – TitleFull: Mid‐childhood developmental and behavioural outcomes in infants with a family history of autism and/or attention deficit hyperactivity disorder.
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            NameFull: Charman, Tony
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            NameFull: Bazelmans, Tessel
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            NameFull: Pasco, Greg
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            NameFull: Begum Ali, Jannath
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            NameFull: Johnson, Mark H.
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              Text: Feb2026
              Type: published
              Y: 2026
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