Thyroid‐Stimulating Hormone (TSH) as a Blood Biomarker in the Acute Clinical Diagnosis of Adult Epilepsy.
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| Title: | Thyroid‐Stimulating Hormone (TSH) as a Blood Biomarker in the Acute Clinical Diagnosis of Adult Epilepsy. |
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| Authors: | Posa, Andreas (AUTHOR), Emmer, Alexander (AUTHOR), Hensel, Ole (AUTHOR), Nerger, Jennifer (AUTHOR), Kornhuber, Malte E. (AUTHOR), Saleem, Suraiya (AUTHOR) |
| Source: | Acta Neurologica Scandinavica. 5/13/2026, Vol. 2026, p1-6. 6p. |
| Subjects: | Thyrotropin, Seizures (Medicine), Acute diseases, Neurological disorders, Epilepsy, Biomarkers |
| Abstract: | Objectives: Epileptic seizures (ESs) are among the most common neurological disorders. Early diagnosis can be supported by laboratory parameters. However, no single biomarker is sufficient to confirm or exclude ES. This study investigates the role of thyroid‐stimulating hormone (TSH) in the acute diagnosis of bilateral tonic–clonic ES in adults. Methods: In this retrospective single‐center study, patients with bilateral tonic–clonic ES admitted between April 2024 and March 2025 were screened. Patients meeting predefined inclusion and exclusion criteria were analyzed. TSH levels were measured within the first hour after ES and on the following day as part of routine clinical care. Results: Thirty‐four patients met the inclusion criteria (mean age: 68.4 ± 19.6 years). TSH levels were significantly elevated within the first hour after ES (mean: 6.39 μU/mL) compared to the following day (mean: 2.37 μU/mL), when values returned to the normal range (p < 0.005; Cohen′s dz = 1.90). Conclusions: TSH levels show a transient postictal elevation in adult bilateral tonic–clonic ES. This finding suggests a potential role as an adjunctive biomarker in acute diagnostics. However, specificity remains uncertain and requires confirmation in prospective controlled studies. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Objectives: Epileptic seizures (ESs) are among the most common neurological disorders. Early diagnosis can be supported by laboratory parameters. However, no single biomarker is sufficient to confirm or exclude ES. This study investigates the role of thyroid‐stimulating hormone (TSH) in the acute diagnosis of bilateral tonic–clonic ES in adults. Methods: In this retrospective single‐center study, patients with bilateral tonic–clonic ES admitted between April 2024 and March 2025 were screened. Patients meeting predefined inclusion and exclusion criteria were analyzed. TSH levels were measured within the first hour after ES and on the following day as part of routine clinical care. Results: Thirty‐four patients met the inclusion criteria (mean age: 68.4 ± 19.6 years). TSH levels were significantly elevated within the first hour after ES (mean: 6.39 μU/mL) compared to the following day (mean: 2.37 μU/mL), when values returned to the normal range (p < 0.005; Cohen′s dz = 1.90). Conclusions: TSH levels show a transient postictal elevation in adult bilateral tonic–clonic ES. This finding suggests a potential role as an adjunctive biomarker in acute diagnostics. However, specificity remains uncertain and requires confirmation in prospective controlled studies. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00016314 |
| DOI: | 10.1155/ane/3171577 |
