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Requirement of bic/microRNA-155 for Normal Immune Function.

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Title: Requirement of bic/microRNA-155 for Normal Immune Function.
Authors: Rodriguez, Antony, Vigorito, Elena, Clare, Simon, Warren, Madhuri V., Couttet, Philippe, Soond, Dalya R., Van Dongen, Stijn, Grocock, Russell J., Das, Partha P., Miska, Eric A., Vetrie, David, Okkenhaug, Klaus, Enright, Anton J., Dougan, Gordon, Turner, Martin, Bradley, Allan
Source: Science (pre-March 2025). 4/27/2007, Vol. 316 Issue 5824, p608-611. 4p.
Subjects: Cells, Heredity, Immunoregulation, Cytokines, RNA, Gene expression, Genomes, Lungs, Homeostasis
Abstract: MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are present in the mammalian genome, genetic studies addressing their physiological roles are at an early stage. We have shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling. We demonstrate a requirement of bic/microRNA-155 for the function of B and I lymphocytes and dendritic cells. Transcriptome analysis of bic/microRNA-155-deficient CD4+ I cells identified a wide spectrum of microRNA-155-regulated genes, including cytokines, chemokines, and transcription factors. Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Requirement of bic/microRNA-155 for Normal Immune Function.
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  Data: <searchLink fieldCode="AR" term="%22Rodriguez%2C+Antony%22">Rodriguez, Antony</searchLink><br /><searchLink fieldCode="AR" term="%22Vigorito%2C+Elena%22">Vigorito, Elena</searchLink><br /><searchLink fieldCode="AR" term="%22Clare%2C+Simon%22">Clare, Simon</searchLink><br /><searchLink fieldCode="AR" term="%22Warren%2C+Madhuri+V%2E%22">Warren, Madhuri V.</searchLink><br /><searchLink fieldCode="AR" term="%22Couttet%2C+Philippe%22">Couttet, Philippe</searchLink><br /><searchLink fieldCode="AR" term="%22Soond%2C+Dalya+R%2E%22">Soond, Dalya R.</searchLink><br /><searchLink fieldCode="AR" term="%22Van+Dongen%2C+Stijn%22">Van Dongen, Stijn</searchLink><br /><searchLink fieldCode="AR" term="%22Grocock%2C+Russell+J%2E%22">Grocock, Russell J.</searchLink><br /><searchLink fieldCode="AR" term="%22Das%2C+Partha+P%2E%22">Das, Partha P.</searchLink><br /><searchLink fieldCode="AR" term="%22Miska%2C+Eric+A%2E%22">Miska, Eric A.</searchLink><br /><searchLink fieldCode="AR" term="%22Vetrie%2C+David%22">Vetrie, David</searchLink><br /><searchLink fieldCode="AR" term="%22Okkenhaug%2C+Klaus%22">Okkenhaug, Klaus</searchLink><br /><searchLink fieldCode="AR" term="%22Enright%2C+Anton+J%2E%22">Enright, Anton J.</searchLink><br /><searchLink fieldCode="AR" term="%22Dougan%2C+Gordon%22">Dougan, Gordon</searchLink><br /><searchLink fieldCode="AR" term="%22Turner%2C+Martin%22">Turner, Martin</searchLink><br /><searchLink fieldCode="AR" term="%22Bradley%2C+Allan%22">Bradley, Allan</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 4/27/2007, Vol. 316 Issue 5824, p608-611. 4p.
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  Data: <searchLink fieldCode="DE" term="%22Cells%22">Cells</searchLink><br /><searchLink fieldCode="DE" term="%22Heredity%22">Heredity</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoregulation%22">Immunoregulation</searchLink><br /><searchLink fieldCode="DE" term="%22Cytokines%22">Cytokines</searchLink><br /><searchLink fieldCode="DE" term="%22RNA%22">RNA</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink><br /><searchLink fieldCode="DE" term="%22Genomes%22">Genomes</searchLink><br /><searchLink fieldCode="DE" term="%22Lungs%22">Lungs</searchLink><br /><searchLink fieldCode="DE" term="%22Homeostasis%22">Homeostasis</searchLink>
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  Data: MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are present in the mammalian genome, genetic studies addressing their physiological roles are at an early stage. We have shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling. We demonstrate a requirement of bic/microRNA-155 for the function of B and I lymphocytes and dendritic cells. Transcriptome analysis of bic/microRNA-155-deficient CD4+ I cells identified a wide spectrum of microRNA-155-regulated genes, including cytokines, chemokines, and transcription factors. Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=24987110
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        Value: 10.1126/science.1139253
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        Text: English
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        StartPage: 608
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      – SubjectFull: Cells
        Type: general
      – SubjectFull: Heredity
        Type: general
      – SubjectFull: Immunoregulation
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      – SubjectFull: Cytokines
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      – SubjectFull: RNA
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      – SubjectFull: Genomes
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      – SubjectFull: Lungs
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      – TitleFull: Requirement of bic/microRNA-155 for Normal Immune Function.
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              Text: 4/27/2007
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