Bibliographic Details
| Title: |
Association study of a functional variant in intron 8 of the dopamine transporter gene and migraine susceptibility. |
| Authors: |
McCallum, L. K., Fernandez, F., Quinlan, S., Macartney, D. P., Lea, R. A., Griffiths, L. R. |
| Source: |
European Journal of Neurology. Jun2007, Vol. 14 Issue 6, p706-707. 2p. 1 Chart. |
| Subjects: |
Migraine, Neurovascular diseases, Genetics, Introns, Dopamine receptors, Genetic polymorphisms |
| Abstract: |
Migraine is a common, genetically influenced neurovascular disorder. The dopamine transporter gene is a candidate for migraine association studies. This study tested a functionally linked variable number tandem repeat (VNTR) in intron 8 of the dopamine transporter gene (DATInt8) in 550 migraine cases (401 with aura, 149 without aura) and 550 non-migraine controls. Chi-squared analysis of the DATInt8 revealed that the allele and genotype frequency distributions for migraine cases (including subtype analysis) and controls were not different ( P > 0.1). These findings offer no evidence for an association of the DATInt8 with migraine with and without aura and therefore do not implicate the dopamine transporter gene as a modifier of migraine risk. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
