Bibliographic Details
| Title: |
Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking. |
| Authors: |
Ambroggi, Frédéric, Turiault, Marc, Milet, Aude, Deroche-Gamonet, Véronique, Parnaudeau, Sébastien, Balado, Eric, Barik, Jacques, van der Veen, Rixt, Maroteaux, Grégoire, Lemberger, Thomas, Schütz, Günther, Lazar, Monique, Marinelli, Michela, Piazza, Pier Vincenzo, Tronche, François |
| Source: |
Nature Neuroscience. Mar2009, Vol. 12 Issue 3, p247-249. 3p. 1 Color Photograph, 2 Graphs. |
| Subjects: |
Psychological stress, Glucocorticoid receptors, Neurons, Neurotransmitter receptors, Dopamine receptors |
| Abstract: |
The glucocorticoid receptor is a ubiquitous transcription factor mediating adaptation to environmental challenges and stress. Selective Nr3c1 (the glucocorticoid receptor gene) ablation in mouse dopaminoceptive neurons expressing dopamine receptor 1a, but not in dopamine-releasing neurons, markedly decreased the motivation of mice to self-administer cocaine, dopamine cell firing and the control exerted by dopaminoceptive neurons on dopamine cell firing activity. In contrast, anxiety was unaffected, indicating that glucocorticoid receptors modify a number of behavioral disorders through different neuronal populations. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
