Induction of vanilloid receptor channel activity by protein kinase C.
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| Title: | Induction of vanilloid receptor channel activity by protein kinase C. |
|---|---|
| Authors: | Premkumar, Louis S., Ahern, Gerard P. |
| Source: | Nature. 12/21/2000-12/28/2000, Vol. 408 Issue 6815, p985. 6p. 1 Color Photograph, 23 Graphs. |
| Subjects: | Protein kinase C, Sensory neurons, Neural transmission, Protein kinases |
| Abstract: | Shows that the activation of protein kinase C induces cloned capsaicin or vanilloid receptor channel activity at room temperature in the absence of any other agonist. Observation of the same effect in native vanilloid receptors from sensory neurons, as well as induction of a vanilloid-sensitive Ca[sub2+] rise by phorbol esters; Finding that the peptide bradykinin and the ligand anandamide both induced and enhanced vanilloid receptor activity; Suggestion that protein kinase C may link a range of stimuli to the activation of vanilloid receptors. |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 3914077 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Induction of vanilloid receptor channel activity by protein kinase C. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Premkumar%2C+Louis+S%2E%22">Premkumar, Louis S.</searchLink><br /><searchLink fieldCode="AR" term="%22Ahern%2C+Gerard+P%2E%22">Ahern, Gerard P.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nature%22">Nature</searchLink>. 12/21/2000-12/28/2000, Vol. 408 Issue 6815, p985. 6p. 1 Color Photograph, 23 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Protein+kinase+C%22">Protein kinase C</searchLink><br /><searchLink fieldCode="DE" term="%22Sensory+neurons%22">Sensory neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+transmission%22">Neural transmission</searchLink><br /><searchLink fieldCode="DE" term="%22Protein+kinases%22">Protein kinases</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Shows that the activation of protein kinase C induces cloned capsaicin or vanilloid receptor channel activity at room temperature in the absence of any other agonist. Observation of the same effect in native vanilloid receptors from sensory neurons, as well as induction of a vanilloid-sensitive Ca[sub2+] rise by phorbol esters; Finding that the peptide bradykinin and the ligand anandamide both induced and enhanced vanilloid receptor activity; Suggestion that protein kinase C may link a range of stimuli to the activation of vanilloid receptors. |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=3914077 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/35050121 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 985 Subjects: – SubjectFull: Protein kinase C Type: general – SubjectFull: Sensory neurons Type: general – SubjectFull: Neural transmission Type: general – SubjectFull: Protein kinases Type: general Titles: – TitleFull: Induction of vanilloid receptor channel activity by protein kinase C. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Premkumar, Louis S. – PersonEntity: Name: NameFull: Ahern, Gerard P. IsPartOfRelationships: – BibEntity: Dates: – D: 21 M: 12 Text: 12/21/2000-12/28/2000 Type: published Y: 2000 Identifiers: – Type: issn-print Value: 00280836 Numbering: – Type: volume Value: 408 – Type: issue Value: 6815 Titles: – TitleFull: Nature Type: main |
| ResultId | 1 |
