Bibliographic Details
| Title: |
Adult hippocampal neurogenesis is involved in anxiety-related behaviors. |
| Authors: |
Revest, J.-M., Dupret, D., Koehl, M., Funk-Reiter, C., Grosjean, N., Piazza, P.-V., Abrous, D. N. |
| Source: |
Molecular Psychiatry. Oct2009, Vol. 14 Issue 10, p959-967. 9p. 5 Graphs. |
| Subjects: |
Developmental neurobiology, Anxiety, Developmental biology, Psychological stress, Emotions |
| Abstract: |
Adult hippocampal neurogenesis is a unique example of structural plasticity, the functional role of which has been a matter of intense debate. New transgenic models have recently shown that neurogenesis participates in hippocampus-mediated learning. Here, we show that transgenic animals, in which adult hippocampal neurogenesis has been specifically impaired, exhibit a striking increase in anxiety-related behaviors. Our results indicate that neurogenesis plays an important role in the regulation of affective states and could be the target of new treatments for anxiety disorders. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
