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Adult hippocampal neurogenesis is involved in anxiety-related behaviors.

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Title: Adult hippocampal neurogenesis is involved in anxiety-related behaviors.
Authors: Revest, J.-M., Dupret, D., Koehl, M., Funk-Reiter, C., Grosjean, N., Piazza, P.-V., Abrous, D. N.
Source: Molecular Psychiatry. Oct2009, Vol. 14 Issue 10, p959-967. 9p. 5 Graphs.
Subjects: Developmental neurobiology, Anxiety, Developmental biology, Psychological stress, Emotions
Abstract: Adult hippocampal neurogenesis is a unique example of structural plasticity, the functional role of which has been a matter of intense debate. New transgenic models have recently shown that neurogenesis participates in hippocampus-mediated learning. Here, we show that transgenic animals, in which adult hippocampal neurogenesis has been specifically impaired, exhibit a striking increase in anxiety-related behaviors. Our results indicate that neurogenesis plays an important role in the regulation of affective states and could be the target of new treatments for anxiety disorders. [ABSTRACT FROM AUTHOR]
Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: <searchLink fieldCode="AR" term="%22Revest%2C+J%2E-M%2E%22">Revest, J.-M.</searchLink><br /><searchLink fieldCode="AR" term="%22Dupret%2C+D%2E%22">Dupret, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Koehl%2C+M%2E%22">Koehl, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Funk-Reiter%2C+C%2E%22">Funk-Reiter, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Grosjean%2C+N%2E%22">Grosjean, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Piazza%2C+P%2E-V%2E%22">Piazza, P.-V.</searchLink><br /><searchLink fieldCode="AR" term="%22Abrous%2C+D%2E+N%2E%22">Abrous, D. N.</searchLink>
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  Data: Adult hippocampal neurogenesis is a unique example of structural plasticity, the functional role of which has been a matter of intense debate. New transgenic models have recently shown that neurogenesis participates in hippocampus-mediated learning. Here, we show that transgenic animals, in which adult hippocampal neurogenesis has been specifically impaired, exhibit a striking increase in anxiety-related behaviors. Our results indicate that neurogenesis plays an important role in the regulation of affective states and could be the target of new treatments for anxiety disorders. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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