Childhood Depression: Pharmacological Therapy/Treatment (Pharmacotherapy of Childhood Depression).
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| Title: | Childhood Depression: Pharmacological Therapy/Treatment (Pharmacotherapy of Childhood Depression). |
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| Authors: | Wagner, Karen Dineen, Ambrosini, Paul J. |
| Source: | Journal of Clinical Child Psychology. Feb2001, Vol. 30 Issue 1, p88-97. 10p. 3 Charts. |
| Subjects: | Antidepressants, Placebos |
| Abstract: | Critiqued the published double-blind, placebo-controlled studies of antidepressant pharmacotherapy in child and adolescent major depressive disorder to assess their overall efficacy. The pharmacological mechanism of antidepressant action also was discussed. At best, antidepressant treatment for depressed youths is only modestly effective. In particular, the tricyclic antidepressants are not superior to placebo; however, early evidence with the selective serotonin reuptake inhibitors is more encouraging. The theoretical basis for this response pattern is discussed from a methodological perspective, from a neurodevelopmental status, and from a biological viewpoint. Study modifications are suggested which could improve some of the methodological limitations apparent in previous clinical drug trials. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Clinical Child Psychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Critiqued the published double-blind, placebo-controlled studies of antidepressant pharmacotherapy in child and adolescent major depressive disorder to assess their overall efficacy. The pharmacological mechanism of antidepressant action also was discussed. At best, antidepressant treatment for depressed youths is only modestly effective. In particular, the tricyclic antidepressants are not superior to placebo; however, early evidence with the selective serotonin reuptake inhibitors is more encouraging. The theoretical basis for this response pattern is discussed from a methodological perspective, from a neurodevelopmental status, and from a biological viewpoint. Study modifications are suggested which could improve some of the methodological limitations apparent in previous clinical drug trials. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 0047228X |
| DOI: | 10.1207/S15374424JCCP3001_10 |
